A synthetic strategy for the construction of 2,2-disubstituted indolin-3-ones from 2-alkynylnitroarenes and ketones has been described. The corresponding indolin-3-one derivatives were afforded in moderate to excellent product yields by using mild conditions. After a Wittig-like process, the key intermediates 3H-indol-3-ones were generated from 2-alkynylnitroarenes, which could be further transformed to the desired products through a Mannich addition.

中文翻译：

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PPh3 介导的 2-炔基硝基苯与酮的 Wittig-Like/Mannich 串联反应合成 2,2-二取代 Indolin-3-One

已经描述了从 2-炔基硝基芳烃和酮构建 2,2-二取代的 indolin-3-ones 的合成策略。相应的 indolin-3-one 衍生物通过使用温和的条件以中等至优异的产品产率提供。经过类似 Wittig 的过程，关键中间体 3 H -indol-3-ones 由 2-炔基硝基芳烃生成，可通过 Mannich 加成进一步转化为所需产物。