BACKGROUND Hydrazide-hydrazone-based compounds are reported for their wider pharmacological potentials. METHODS In the present work, we synthesized 10 new Schiff-based-aryl-carbohydrazide (3a-3e) and (4a-4e) analogues and characterized further using standard spectroscopic techniques including NMR, mass and FT-IR. Moreover, all synthesized compounds were subjected to in vitro anti-TB, anti-microbial, antioxidant and anti-MCF-7 cell line studies. RESULTS Our results suggested that compounds have strong potencies against studied microbial species (such as 3a, 3b and 3c, (anti-TB activity: MIC value of 1.6 μg/mL; 3c:80.23 % inhibition at 200 μg/mL against MCF-7). Synthesized compounds (3a-3e) and (4a-4e) were also retained with higher docking scores than standards like ciprofloxacin; when studied for their molecular docking analysis against common anti-bacterial (pdb id:1d7u; 3a: -4.909 kcal/mol), common anti-fungal (pdb id:1ai9; 3b: -6.122 kcal/mol) and enoyl acyl reductase enzyme (pdb id:2x22; 3c: docking score: -4.194 kcal/mol)) targets. CONCLUSION Thus, considering promising results for Schiff-based-aryl-carbohydrazides, these compounds may emerge as a new class for developing potent anti-microbial agents in the near future.

中文翻译：

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新型芳基碳酰肼类似物的合成、分子对接、抗氧化剂、抗结核病和有效的 MCF-7 抗癌研究。

背景技术报道了基于酰肼-腙的化合物具有更广泛的药理潜力。方法 在目前的工作中，我们合成了 10 种新的席夫基芳基碳酰肼 (3a-3e) 和 (4a-4e) 类似物，并使用包括 NMR、质谱和 FT-IR 在内的标准光谱技术进一步表征。此外，所有合成的化合物都进行了体外抗结核病、抗微生物、抗氧化和抗 MCF-7 细胞系研究。结果 我们的结果表明化合物对研究的微生物物种（如 3a、3b 和 3c）具有很强的效力（抗结核活性：MIC 值为 1.6 μg/mL；3c：200 μg/mL 时对 MCF-7 的抑制率为 80.23% ). 合成的化合物 (3a-3e) 和 (4a-4e) 也被保留，其对接分数高于环丙沙星等标准品；当研究它们针对常见抗菌剂 (pdb id:1d7u; 3a: -4.909 kcal/mol)、常见抗真菌剂 (pdb id:1ai9; 3b: -6.122 kcal/mol) 和烯酰基酰基还原酶的分子对接分析时(pdb id:2x22; 3c: 对接分数: -4.194 kcal/mol)) 目标。结论 因此，考虑到席夫基芳基碳酰肼的可喜结果，这些化合物可能在不久的将来成为开发有效抗微生物剂的新类别。