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Temperature-Sensitive Anti-Inflammatory Organohydrogels Containing Janus Particle Stabilized Phase-Change Microinclusions
ACS Nano ( IF 17.1 ) Pub Date : 2022-06-14 , DOI: 10.1021/acsnano.2c03940
Haoguan Gui 1, 2 , Tiantian Yang 1, 3 , Li-Li Li 4 , Fuxin Liang 1 , Zhenzhong Yang 1
Affiliation  

A fabrication strategy for multifunctional organohydrogels is proposed, which combines phase-change microinclusions within a double-network (DN) hydrogel under the stabilization of Janus particles. Janus particles possess reactivity and colloidal stability for more robust organohydrogels, while the interstice among Janus particles enhances the mass transfer between the phase interfaces. Moreover, DN hydrogels are achieved through dynamic cross-linking networks, endowing organohydrogels with injectability and self-healing performance. Phase-change microinclusions are beneficial to the organohydrogels with temperature-responsive mechanical property and temperature-programed shape-memory performance. Organohydrogels can be employed for temperature therapy through the melting-crystallization process of phase-change microinclusions. Simultaneously, the payloads within microinclusions can be released for antibacteria upon melting the encapsulated wax. The organohydrogels can be served as an ideal dressing with temperature-responsive mechanical property, temperature therapy effectiveness, and temperature-triggered antibacterial ability.

中文翻译:

含有 Janus 粒子稳定相变微夹杂物的温度敏感型抗炎有机水凝胶

提出了一种多功能有机水凝胶的制造策略,该策略在 Janus 粒子的稳定作用下将相变微包裹体结合在双网络 (DN) 水凝胶中。Janus 颗粒具有反应性和胶体稳定性,可形成更坚固的有机水凝胶,而 Janus 颗粒之间的间隙增强了相界面之间的传质。此外,DN 水凝胶是通过动态交联网络实现的,赋予有机水凝胶可注射性和自愈性能。相变微夹杂物有利于有机水凝胶的温度响应机械性能和温度程序形状记忆性能。有机水凝胶可通过相变微包裹体的熔融-结晶过程用于温度疗法。同时,微包裹体中的有效载荷可以在封装的蜡熔化后释放出来用于抗菌。有机水凝胶可以作为一种理想的敷料,具有温度响应的机械性能、温度治疗效果和温度触发的抗菌能力。
更新日期:2022-06-14
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