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Harmonization and standardization of data for a pan-European cohort on SARS- CoV-2 pandemic
npj Digital Medicine ( IF 15.2 ) Pub Date : 2022-06-14 , DOI: 10.1038/s41746-022-00620-x
Eugenia Rinaldi 1 , Caroline Stellmach 1 , Naveen Moses Raj Rajkumar 1 , Natascia Caroccia 2 , Chiara Dellacasa 3 , Maddalena Giannella 2 , Mariana Guedes 4 , Massimo Mirandola 4 , Gabriella Scipione 3 , Evelina Tacconelli 4 , Sylvia Thun 1
Affiliation  

The European project ORCHESTRA intends to create a new pan-European cohort to rapidly advance the knowledge of the effects and treatment of COVID-19. Establishing processes that facilitate the merging of heterogeneous clusters of retrospective data was an essential challenge. In addition, data from new ORCHESTRA prospective studies have to be compatible with earlier collected information to be efficiently combined. In this article, we describe how we utilized and contributed to existing standard terminologies to create consistent semantic representation of over 2500 COVID-19-related variables taken from three ORCHESTRA studies. The goal is to enable the semantic interoperability of data within the existing project studies and to create a common basis of standardized elements available for the design of new COVID-19 studies. We also identified 743 variables that were commonly used in two of the three prospective ORCHESTRA studies and can therefore be directly combined for analysis purposes. Additionally, we actively contributed to global interoperability by submitting new concept requests to the terminology Standards Development Organizations.



中文翻译:

SARS-CoV-2 大流行泛欧队列数据的协调和标准化

欧洲项目 ORCHESTRA 打算创建一个新的泛欧洲队列,以快速推进对 COVID-19 效果和治疗的了解。建立有助于合并异构追溯数据集群的流程是一项基本挑战。此外,来自新的 ORCHESTRA 前瞻性研究的数据必须与早期收集的信息兼容,才能有效地组合。在本文中,我们描述了我们如何利用现有标准术语并对其做出贡献,以创建来自三项 ORCHESTRA 研究的 2500 多个 COVID-19 相关变量的一致语义表示。目标是在现有项目研究中实现数据的语义互操作性,并为可用于设计新的 COVID-19 研究的标准化元素创建一个通用基础。我们还确定了三项前瞻性 ORCHESTRA 研究中的两项中常用的 743 个变量,因此可以直接组合用于分析目的。此外,我们通过向术语标准开发组织提交新概念请求,为全球互操作性做出了积极贡献。

更新日期:2022-06-14
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