Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.

中文翻译：

---

PRC2 保护人类干细胞的效力

人们普遍认为人类幼稚多能干细胞具有不受限制的分化成胚胎和胚胎外谱系的能力。然而，两项新研究现在揭示了 Polycomb 抑制复合物 2 (PRC2) 作为谱系守门人的作用，可以屏蔽这些细胞的效力。