An easy-to-handle protocol for the synthesis of an efficient electrophilic (phenylsulfonyl)difluoromethylating reagent, namely, the S-([phenylsulfonyl]difluoromethyl)-dibenzothiophenium salt I, is depicted. The latter was synthesized on approximately 40 g scale in a three-step/one-purification sequence from commercially available or easy-to-synthesize starting materials with an estimated global prize of about 10.6 €/g. The bench-stable reagent I was found to be air- and moisture-tolerant. By changing the counter anion, a small library of electrophilic sources (reagents I–III) is now available for the (phenylsulfonyl)difluoromethylation reaction. Differential scanning calorimetry (DSC) measurements have been also carried out on the different salts (I–III) along with a key intermediate to ensure a safe process.

中文翻译：

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具有成本效益的多克可扩展合成耐贮存的亲电子（苯磺酰基）二氟甲基化试剂

描述了一种用于合成有效的亲电子 (苯磺酰基) 二氟甲基化试剂 (即S -([苯磺酰基] 二氟甲基)-二苯并噻吩盐I ) 的易于处理的协议。后者是从市售或易于合成的起始材料以三步/一次纯化序列以大约 40 g 的规模合成的，估计全球奖金约为 10.6 欧元/克。工作台稳定的试剂I被发现是耐空气和耐湿的。通过改变抗衡阴离子，一个小的亲电源库（试剂I – III) 现在可用于 (苯磺酰基) 二氟甲基化反应。还对不同的盐 ( I - III ) 以及关键中间体进行了差示扫描量热法 (DSC) 测量，以确保过程安全。