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Global, regional, and national childhood cancer burden, 1990–2019: An analysis based on the Global Burden of Disease Study 2019
Journal of Advanced Research ( IF 10.7 ) Pub Date : 2022-06-11 , DOI: 10.1016/j.jare.2022.06.001
Ying Wu 1 , Yujiao Deng 1 , Bajin Wei 2 , Dong Xiang 3 , Jingjing Hu 4 , Peng Zhao 5 , Shuai Lin 6 , Yi Zheng 1 , Jia Yao 7 , Zhen Zhai 1 , Shuqian Wang 7 , Weiyang Lou 7 , Si Yang 1 , Dai Zhang 6 , Jun Lyu 8 , Zhijun Dai 1
Affiliation  

Introduction

Cancer is the leading cause of death among children.

Objectives

We report on the latest estimates of the burden of cancer among children at the global, regional, and national levels from 1990 to 2019.

Methods

Based on the Global Burden of Disease Study 2019, children’s cancer data were analyzed by sex, age, year, and location. Age-standardized rates were used to compare the burdens among regions and nations. Joinpoint analysis was applied to assess the temporal trend of the global childhood cancer burden.

Results

In 2019, 291,319 (95% uncertainty interval [UI], 254,239 to 331,993) new cases and 98,834 (86,124 to 113,581) deaths from childhood cancer were documented globally. Further, 8,302,464 (7,230,447 to 9,555,118) DALYs and 1,806,630 (1,567,808 to 2,089,668) prevalent cases were recorded in the same year. Age-standardized incidence and prevalence rates of childhood cancer were greatest in higher SDI settings and increased most significantly in Australasia and Southern Latin America over the last 30 years. However, although age-standardized death and DALY rates of childhood cancer have remarkably decreased in all regions since 1990, countries with a lower SDI showed the highest rates in 2019, particularly in countries in Eastern Sub-Saharan Africa. Among all cancers, leukemia has shown the largest decrease in burden since 1990. Despite this, leukemia was still the most common cancer and the leading cause of death among children in 2019, followed by brain and central nervous system cancer.

Conclusions

On a global scale, the childhood cancer burden has significantly fallen over the last 30 years, but is still higher in lower SDI countries. Effective interventions and collaborations among nations should be facilitated to improve healthcare among children with cancer in countries with lower SDI.



中文翻译:

1990-2019 年全球、区域和国家儿童癌症负担:基于 2019 年全球疾病负担研究的分析

介绍

癌症是儿童死亡的主要原因。

目标

我们报告了 1990 年至 2019 年全球、区域和国家层面儿童癌症负担的最新估计。

方法

根据 2019 年全球疾病负担研究,儿童癌症数据按性别、年龄、年份和地点进行了分析。年龄标准化率用于比较地区和国家之间的负担。应用连接点分析来评估全球儿童癌症负担的时间趋势。

结果

2019 年,全球记录了 291,319 例(95% 不确定区间 [UI],254,239 至 331,993 例)新病例和 98,834 例(86,124 至 113,581 例)儿童癌症死亡病例。此外,同年记录了 8,302,464(7,230,447 至 9,555,118)个 DALY 和 1,806,630(1,567,808 至 2,089,668)例流行病例。儿童癌症的年龄标准化发病率和患病率在 SDI 较高的环境中最高,在过去 30 年中在澳大拉西亚和拉丁美洲南部增长最为显着。然而,尽管自 1990 年以来所有地区的儿童癌症年龄标准化死亡率和 DALY 率均显着下降,但 SDI 较低的国家在 2019 年的发病率最高,尤其是在撒哈拉以南非洲东部国家。在所有癌症中,白血病的负担自 1990 年以来下降幅度最大。尽管如此,

结论

在全球范围内,儿童癌症负担在过去 30 年中显着下降,但在 SDI 较低的国家仍然更高。应促进国家之间的有效干预和合作,以改善 SDI 较低国家癌症儿童的医疗保健。

更新日期:2022-06-11
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