We report the synthesis of redox- and pH-sensitive block copolymer micelles that contain chiral cores composed of helical poly(aryl isocyanide)s. Pentafluorophenyl (PFP) ester-containing micelles synthesised via nickel-catalysed coordination polymerisation-induced self-assembly (NiCCo-PISA) of helical poly(aryl isocyanide) amphiphilic diblock copolymers are modified post-polymerisation with various diamines to introduce cross-links and/or achieve stimulus-sensitive nanostructures. The successful introduction of the diamines is confirmed by Fourier-transform infrared spectroscopy (FT-IR), while the stabilisation effect of the cross-linking is explored by dynamic light scattering (DLS). The retention of the helicity of the core-forming polymer block is verified by circular dichroism (CD) spectroscopy and the stimuli-responsiveness of the nanoparticles towards a reducing agent (L-glutathione, GSH) and pH is evaluated by following the change in the size of the nanoparticles by DLS. These stimuli-responsive nanoparticles could find use in applications such as drug delivery, nanosensors or biological imaging.

中文翻译：

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NiCCo-PISA螺旋聚芳基异氰化物开发的刺激响应和核心交联胶束

我们报告了氧化还原和 pH 敏感嵌段共聚物胶束的合成，这些胶束包含由螺旋聚 (芳基异氰化物) 组成的手性核。通过合成的五氟苯基 (PFP​​) 酯胶束螺旋聚（芳基异氰化物）两亲二嵌段共聚物的镍催化配位聚合诱导自组装（NiCCo-PISA）在聚合后用各种二胺进行改性，以引入交联和/或实现对刺激敏感的纳米结构。通过傅里叶变换红外光谱 (FT-IR) 证实了二胺的成功引入，而通过动态光散射 (DLS) 探索了交联的稳定效果。通过圆二色 (CD) 光谱和纳米粒子对还原剂的刺激响应性 ( L-谷胱甘肽，GSH) 和 pH 值通过 DLS 跟踪纳米颗粒大小的变化来评估。这些刺激响应纳米粒子可用于药物输送、纳米传感器或生物成像等应用。