Abstract

Three new hasubanan-type alkaloids, stephalonine Q (1), stephalonine R (2) and stephalonine S (3), together with four known alkaloids, isolonganone (4), eletefine (5), aurantiamide (6), N-cinnamoyltyramine (7), were isolated from the whole plant of Stephania longa. Their structures were identified by NMR, HR-ESI-MS, CD methods and x-ray crystallography, as well as by comparison with the literature data. All isolated compounds were evaluated for their antimicrobial activities against five bacteria in vitro. Compound 5 displayed inhibitory activity against only S. aureus, with an MIC value of 50 μg/mL.

中文翻译：

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三种来自千金藤的新哈苏巴南型生物碱

摘要

三种新的哈苏巴南型生物碱：千金藤碱 Q (1)、千金藤碱 R (2) 和千金藤碱 S (3)，以及四种已知生物碱：异龙酮 (4)、依替芬 (5)、橙酰胺 (6)、N-肉桂酰胺 ( 7)、从千金藤全草中分离得到。通过NMR、HR-ESI-MS、CD方法和X射线晶体学鉴定了它们的结构，并与文献数据进行了比较。所有分离的化合物均在体外对五种细菌的抗菌活性进行了评估。化合物 5 仅对金黄色葡萄球菌具有抑制活性，MIC 值为 50 μg/mL。