Abstract

Objectives

The relationship between optimism and cognitive functioning is not fully understood. We examined the association of optimism with risk of mild cognitive impairment (MCI) and dementia in the Women’s Health Initiative Memory Study (WHIMS).

Methods

Optimism was measured by the Life Orientation Test-Revised (LOT-R) total score, and optimism and pessimism subscales. A panel of experts adjudicated cognitive endpoints based on annual cognitive assessments. We used cox proportional hazard regression models to examine the association of LOT-R total score and optimism and pessimism sub-scores with MCI/dementia. We also examined the relationship between vascular disease, LOT-R total score, optimism and pessimism, and cognition.

Results

Mean age was 70.5 (SD = 3.9) years. The sample (N = 7249) was 87% white, and 29.8% of participants had < 12 years of education. Total LOT-R score (HR = 0.96, 95% CI: 0.94, 0.98, p < 0.001) was associated with lower risk of combined MCI or dementia. More pessimism (HR = 1.08, 95% CI: 1.05, 1.11, p < 0.0001) was associated with higher risk of MCI or dementia after adjustment for ethnicity, education, vascular disease, and depression. No significant relationships emerged from the optimism subscale.

Conclusion

These data suggest that less pessimism, but not more optimism, was associated with a lower risk of MCI and dementia.

中文翻译：

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绝经后女性乐观、MCI 和痴呆之间的关系

摘要

目标

乐观与认知功能之间的关系尚未完全了解。我们在女性健康倡议记忆研究 (WHIMS) 中研究了乐观情绪与轻度认知障碍 (MCI) 和痴呆症风险的关联。

方法

乐观程度通过生活取向测试修订版 (LOT-R) 总分以及乐观和悲观分量表来衡量。专家小组根据年度认知评估来判定认知终点。我们使用 Cox 比例风险回归模型来检查 LOT-R 总分以及乐观和悲观子分数与 MCI/痴呆的关联。我们还检查了血管疾病、LOT-R 总分、乐观和悲观以及认知之间的关系。

结果

平均年龄为 70.5 (SD = 3.9) 岁。样本 ( N  = 7249) 中 87% 是白人，29.8% 的参与者受教育年限<12 年。LOT-R 总评分（HR = 0.96，95% CI：0.94、0.98，p  < 0.001）与合并 MCI 或痴呆的风险较低相关。调整种族、教育程度、血管疾病和抑郁症后，悲观程度越高（HR = 1.08，95% CI：1.05、1.11，p  < 0.0001）与 MCI 或痴呆风险越高相关。乐观分量表没有出现显着的关系。

结论

这些数据表明，较少的悲观情绪，而不是更多的乐观情绪，与较低的 MCI 和痴呆风险相关。