Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain amino acids (BCAA) circulatory levels. At the same time, its activity yields a higher energy expenditure, thereby conferring protection against cardiometabolic diseases. Our knowledge on the mechanisms of uptake and intracellular metabolism of such energy substrates into thermogenic fat has meaningfully evolved in recent years. This has allowed us to better understand how the thermogenic machinery processes those molecules to utilize them as substrates for heating up the body. Here, we discuss recent advances in the molecular and cellular regulatory process that governs the uptake and metabolism of such substrates within thermogenic fat.

由于其从循环中清除大量营养素并利用它们产生热量的独特能力，产热脂肪能够调节葡萄糖、脂质和支链氨基酸 (BCAA) 循环水平。同时，它的活性产生更高的能量消耗，从而提供对心脏代谢疾病的保护。近年来，我们对这些能量底物向产热脂肪的摄取和细胞内代谢机制的了解有了有意义的发展。这使我们能够更好地了解产热机制如何处理这些分子以利用它们作为加热身体的底物。在这里，我们讨论了分子和细胞调节过程的最新进展，该过程控制产热脂肪中此类底物的摄取和代谢。