Interleukin-6 (IL-6) is a very important cytokine and an early predictor of survival in febrile patients (eg, patients with COVID-19). With the outbreak of the COVID-19 in the world, the significance of medical detection of interleukin 6 has gradually become prominent. A method to point-of-care(POCT) diagnosis and monitoring of IL-6 levels in patients is urgently needed. In this work, an up-conversion luminescence system (ULS) based on upconverting nanoparticles (UCNs) for quantitative detection of IL-6 was designed. The ULS consists of Micro Controller Units (MCU), transmission device, laser, image acquisition module, Bluetooth module, etc. Through hardware system acquisition and image software algorithm processing, we obtain a limit of detection (LOD) of IL-6 at 1 ng/mL, and the quantitative range is from 1 to 200 ng/mL. The system is handheld and has great detection accuracy. The detection time is 10 minutes. In addition, the system can access mobile device terminals (smartphones, personal computers, etc.) or 5G cloud servers via Bluetooth and WIFI. Patients and family members can view medical data through mobile terminals, and the data stored in the 5G cloud server can be used for edge computing and big data analysis. It is suitable for the early diagnosis of infectious diseases such as COVID-19 and has good application prospects.

中文翻译：

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用于 IL-6 定量检测的上转换发光系统

白细胞介素 6 (IL-6) 是一种非常重要的细胞因子，是发热患者（例如 COVID-19 患者）生存的早期预测因子。随着COVID-19在全球的爆发，白细胞介素6的医学检测意义逐渐凸显。迫切需要一种即时 (POCT) 诊断和监测患者 IL-6 水平的方法。在这项工作中，设计了一种基于上转换纳米粒子 (UCN) 的上转换发光系统 (ULS)，用于定量检测 IL-6。ULS由微控制器（MCU）、传输装置、激光器、图像采集模块、蓝牙模块等组成。通过硬件系统采集和图像软件算法处理，我们得到IL-6的检测限（LOD）为1 ng/mL，定量范围为1～200 ng/mL。该系统为手持式，检测精度高。检测时间为10分钟。此外，系统可通过蓝牙和WIFI接入移动设备终端（智能手机、个人电脑等）或5G云服务器。患者和家属可通过移动终端查看医疗数据，存储在5G云服务器中的数据可用于边缘计算和大数据分析。适用于COVID-19等传染病的早期诊断，具有良好的应用前景。5G云服务器存储的数据可用于边缘计算和大数据分析。适用于COVID-19等传染病的早期诊断，具有良好的应用前景。5G云服务器存储的数据可用于边缘计算和大数据分析。适用于COVID-19等传染病的早期诊断，具有良好的应用前景。