Outcomes of cirrhotic patients with pre-capillary pulmonary hypertension and pulmonary vascular resistance between 2 and 3 Wood Units,European Respiratory Journal

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Outcomes of cirrhotic patients with pre-capillary pulmonary hypertension and pulmonary vascular resistance between 2 and 3 Wood Units
European Respiratory Journal ( IF 24.3 ) Pub Date : 2022-08-04 , DOI: 10.1183/13993003.00107-2022
Marie Caroline Certain _{1,

2,

3} , Audrey Baron _{1,

2,

3} , Matthieu Turpin _{1,

2,

3} , Nathan Ebstein _{1,

2,

3} , Athénaïs Boucly _{1,

2,

3} , Antoine Beurnier _{1,

2,

3} , Mitja Jevnikar _{1,

2,

3} , Anne Roche _{1,

2,

3} , Sophia Keddache _{1,

2,

3} , Sophie Bulifon _{1,

2,

3} , Andrei Seferian _{1,

2,

3} , Xavier Jaïs _{1,

2,

3} , David Montani _{1,

2,

3} , Marc Humbert _{1,

2,

3} , Olivier Sitbon _{1,

2,

3} , Laurent Savale _{2,

3,

4}

Affiliation

Portopulmonary hypertension (PoPH) is a subtype of pulmonary arterial hypertension (PAH) complicating the course of portal hypertension [1, 2]. Similar to other causes of PAH, PoPH is characterised by a progressive structural and functional remodelling of small pulmonary arteries leading to pre-capillary pulmonary hypertension defined by a mean pulmonary artery pressure (mPAP) ≥25 mmHg, normal pulmonary artery wedge pressure (PAWP) ≤15 mmHg and raised pulmonary vascular resistance (PVR) >3 Wood Units (WU) [1]. PoPH negatively impacts survival of patients with portal hypertension. Early detection of PoPH is of particular importance because it is treatable with PAH drugs and basic therapies such as diuretics [1, 3].

中文翻译：

毛细血管前肺动脉高压和肺血管阻力在 2 到 3 个伍德单位之间的肝硬化患者的结局

门静脉高压症 (PoPH) 是肺动脉高压 (PAH) 的一种亚型，使门静脉高压症的病程复杂化 [1, 2]。与 PAH 的其他原因相似，PoPH 的特征是小肺动脉进行性结构和功能重塑，导致毛细血管前肺动脉高压，定义为平均肺动脉压 (mPAP) ≥25 mmHg，肺动脉楔压正常 (PAWP) ≤15 mmHg 且肺血管阻力 (PVR) 升高 >3 Wood Units (WU) [1]。PoPH 对门静脉高压症患者的生存产生负面影响。PoPH 的早期检测特别重要，因为它可以用 PAH 药物和利尿剂等基础疗法进行治疗 [1, 3]。

更新日期：2022-08-04

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