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Reactive oxygen nano-generators for cancer therapy
Progress in Materials Science ( IF 37.4 ) Pub Date : 2022-06-10 , DOI: 10.1016/j.pmatsci.2022.100974
Dnyaneshwar Kalyane , Devendra Choudhary , Suryanarayana Polaka , Hanmant Goykar , Tukaram Karanwad , Kuldeep Rajpoot , Rakesh Kumar Tekade

Reactive oxygen species (ROS) play a vital role in the biological process. Interestingly, based on the concentration of the ROS level, they can be beneficial or detrimental to tumor cell growth. Induction of disproportionality in the redox homeostasis by increased accumulation of free radicals, predominantly ROS, can assist cancer treatment. The elevated level of ROS inside the tumor damages the vital biomolecules of tumor cells, such as proteins, lipids, and nucleic acids. Hence, fine-tuning the ROS level in the tumor cells by novel therapeutics can help in the overproduction of ROS, and this further helps in ROS-induced apoptotic signaling. The present review discusses the role of ROS in cancer cells, their mechanism of action in cancer cell death, and the challenges associated with ROS therapy. The mechanisms of ROS generation by nanogenerators were also discussed. Furthermore, this review also explicates various ROS nanogenerators for selective generation and accumulation of ROS in tumor tissue for achieving higher anticancer activity.



中文翻译:

用于癌症治疗的活性氧纳米发生器

活性氧(ROS)在生物过程中起着至关重要的作用。有趣的是,根据 ROS 水平的浓度,它们可能对肿瘤细胞生长有益或有害。通过增加自由基(主要是 ROS)的积累来诱导氧化还原稳态中的不成比例,可以帮助癌症治疗。肿瘤内升高的 ROS 水平会损害肿瘤细胞的重要生物分子,例如蛋白质、脂质和核酸。因此,通过新疗法微调肿瘤细胞中的 ROS 水平有助于 ROS 的过度产生,这进一步有助于 ROS 诱导的细胞凋亡信号传导。本综述讨论了 ROS 在癌细胞中的作用、它们在癌细胞死亡中的作用机制以及与 ROS 治疗相关的挑战。还讨论了纳米发电机产生 ROS 的机制。此外,本综述还阐明了各种 ROS 纳米发生器用于在肿瘤组织中选择性生成和积累 ROS 以实现更高的抗癌活性。

更新日期:2022-06-10
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