With the aim of providing safer replacements for the K_V7 potassium channel openers flupirtine and retigabine, the oxidation-sensitive triaminoaryl scaffold was modified in a ligand-based approach in order to obtain oxidation-resistant carba derivatives. Some of these novel analogues have a negligible risk for the formation of quinoid metabolites and possess potent K_V7.2/3 opening activity.

中文翻译：

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氟吡汀和瑞替加滨的卡巴类似物，具有改善的抗氧化性和降低醌类代谢物形成的风险

为了为 K _{V 7 钾通道开放剂氟吡汀和瑞替加滨}提供更安全的替代品，以基于配体的方法对氧化敏感的三氨基芳基支架进行了修饰，以获得抗氧化的卡巴衍生物。其中一些新型类似物形成醌类代谢物的风险可以忽略不计，并具有有效的 K _V 7.2/3 开放活性。