Cardiovascular complications of pregnancy have risen substantially over the past decades, and now account for the majority of pregnancy-induced maternal deaths, as well as having substantial long-term consequences on maternal cardiovascular health. The causes and pathophysiology of these complications remain poorly understood, and therapeutic options are limited. Preclinical models represent a crucial tool for understanding human disease. We review here advances made in preclinical models of cardiovascular complications of pregnancy, including preeclampsia and peripartum cardiomyopathy, with a focus on pathological mechanisms elicited by the models and on relevance to human disease.

中文翻译：

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妊娠心血管并发症的动物模型

在过去几十年中，妊娠的心血管并发症大幅增加，现在占妊娠引起的孕产妇死亡的大部分，并对孕产妇心血管健康产生重大的长期影响。这些并发症的原因和病理生理学仍然知之甚少，治疗选择有限。临床前模型是了解人类疾病的重要工具。我们在此回顾妊娠期心血管并发症（包括先兆子痫和围产期心肌病）临床前模型的进展，重点关注模型引发的病理机制以及与人类疾病的相关性。