Abstract

Objective

Individuals who are family history positive (FHP) for substance use problems have increased risk for substance use, substance use disorders (SUDs), and psychopathology. Links between FHP status and prescription drug misuse (PDM) have not been well investigated; this study examined PDM in adults 50 and older by FHP status.

Methods

Data were from the US NESARC-III (n = 14,667). Participants reported their opioid PDM, tranquilizer/sedative PDM, SUD, psychopathology, and family history status (i.e. first- and second-degree relatives with alcohol/substance use problems). Prevalence rates were estimated by FHP status, and logistic regressions compared FHP and family history negative (FHN) groups.

Results

FHP status was associated with significantly higher rates of PDM (e.g. past-year opioid PDM, FHP: 3.8%, FHN: 1.5%) and SUD from PDM (e.g. past-year SUD, FHP: 1.2%, FHN: 0.2%); also, prevalence varied by family history density, with the highest rates in those with three or more relatives with substance use problems (e.g. past-year opioid PDM: 5.5%). Overall, 32.2% of FHP individuals with past-year PDM had past-year co-occurring SUD and psychopathology diagnoses, versus 11.0% of FHN individuals.

Conclusion

FHP status could inform treatment decisions in adults 50 and older with conditions for which prescription opioids or tranquilizer/sedatives are indicated.

中文翻译：

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50 岁及以上成年人的物质使用障碍家族史和滥用处方药的可能性

摘要

客观的

物质使用问题家族史呈阳性 (FHP) 的个人发生物质使用、物质使用障碍 (SUD) 和精神病理学的风险增加。FHP 状态与处方药滥用 (PDM) 之间的联系尚未得到充分调查；这项研究通过 FHP 状态检查了 50 岁及以上成年人的 PDM。

方法

数据来自美国 NESARC-III ( n  = 14,667)。参与者报告了他们的阿片类药物 PDM、镇静剂/镇静剂 PDM、SUD、精神病理学和家族史状况（即有酒精/药物使用问题的一级和二级亲属）。患病率由 FHP 状态估计，逻辑回归比较 FHP 和家族史阴性 (FHN) 组。

结果

FHP 状态与 PDM（例如去年阿片类药物 PDM，FHP：3.8%，FHN：1.5%）和 PDM 的 SUD（例如去年 SUD，FHP：1.2%，FHN：0.2%）显着相关；此外，患病率因家族史密度而异，其中三个或更多亲属有物质使用问题的患病率最高（例如去年阿片类药物 PDM：5.5%）。总体而言，过去一年患有 PDM 的 FHP 个体中有 32.2% 在过​​去一年中同时发生过 SUD 和精神病理学诊断，而 FHN 个体中这一比例为 11.0%。

结论

FHP 状态可以为 50 岁及以上成人的治疗决策提供信息，这些情况需要处方阿片类药物或镇静剂/镇静剂。