Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) is a rare malignant neoplasm accounting for <1% of pancreatic masses. Very few case reports and small series have described the cytomorphological features of this entity. We report a case of UC-OGC arising in the pancreas presenting with liver metastasis in a 56-year-old man diagnosed by guided fine-needle aspiration cytology (FNAC). A characteristic biphasic pattern comprising of malignant mononuclear cells with scattered bland giant cells were the hallmark features for cytological diagnosis. Our case along with review of cytology literature emphasize the utility of FNAC and the cell block in the diagnosis and management of this rare entity.

中文翻译：

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细胞学显示胰腺破骨细胞样巨细胞未分化癌1例并文献复习

具有破骨细胞样巨细胞的未分化癌（UC-OGC）是一种罕见的恶性肿瘤，占胰腺肿块的<1%。很少有病例报告和小型系列描述了该实体的细胞形态学特征。我们报告一例 56 岁男性胰腺出现 UC-OGC，表现为肝转移，经引导细针穿刺细胞学 (FNAC) 诊断。由恶性单核细胞和散在的温和巨细胞组成的特征性双相模式是细胞学诊断的标志性特征。我们的案例以及对细胞学文献的回顾强调了 FNAC 和细胞块在这种罕见实体的诊断和管理中的效用。