Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance,Cell Metabolism

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Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance
Cell Metabolism ( IF 29.0 ) Pub Date : 2022-06-09 , DOI: 10.1016/j.cmet.2022.05.007
Yanru Wu ₁ , Chi Wut Wong ₂ , Eric N Chiles ₃ , Allyson L Mellinger ₄ , Hosung Bae ₅ , Sunhee Jung ₅ , Ted Peterson ₆ , Jamie Wang ₆ , Marcos Negrete ₆ , Qiang Huang ₇ , Lihua Wang ₆ , Cholsoon Jang ₅ , David C Muddiman ₈ , Xiaoyang Su ₉ , Ian Williamson ₁₀ , Xiling Shen ₁₁

Affiliation

Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08903, USA.
FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Department of Pediatric Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710004, China.
FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695, USA.
Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08903, USA; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Gastroenterology Division, Department of Medicine, Duke University, Durham, NC 27710, USA.
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.

Dietary fructose, especially in the context of a high-fat western diet, has been linked to type 2 diabetes. Although the effect of fructose on liver metabolism has been extensively studied, a significant portion of the fructose is first metabolized in the small intestine. Here, we report that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood. Chronic high systemic glycerate levels induce glucose intolerance by slowly damaging pancreatic islet cells and reducing islet sizes. Our findings provide a link between dietary fructose and diabetes that is modulated by dietary fat.

中文翻译：

肠道果糖代谢产生的甘油诱导胰岛细胞损伤和葡萄糖不耐受

膳食果糖，尤其是高脂肪西方饮食中的果糖，与 2 型糖尿病有关。尽管果糖对肝脏代谢的影响已被广泛研究，但很大一部分果糖首先在小肠中代谢。在这里，我们报告膳食脂肪增强肠道果糖代谢，从而将甘油酸释放到血液中。慢性高全身甘油酸盐水平通过缓慢损害胰岛细胞和减小胰岛大小而诱导葡萄糖不耐受。我们的研究结果提供了膳食果糖和糖尿病之间的联系，这种联系是由膳食脂肪调节的。

更新日期：2022-06-09

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