In a recent Science study, an advanced mutational signature analysis was performed on an unprecedentedly large set of cancer whole-genome sequences across multiple organs. This work introduces a computational framework to identify common and rare mutational signatures and provides insights into their biological interpretation.

中文翻译：

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解决癌症发展中的突变特征

在最近的一项《科学研究》中，对跨多个器官的前所未有的大量癌症全基因组序列进行了先进的突变特征分析。这项工作引入了一个计算框架来识别常见和罕见的突变特征，并提供对其生物学解释的见解。