Biodegradable magnesium (Mg) alloys exhibit great potential for use as temporary structures in tissue engineering applications. Such degradable implants require no secondary surgery for their removal. In addition, their comparable mechanical properties with the human bone, together with excellent biocompatibility, make them a suitable candidate for fracture treatments. Nevertheless, some challenges remain. Fast degradation of the Mg-based alloys in physiological environments leads to a loss of the mechanical support that is needed for complete tissue healing and also to the accumulation of hydrogen gas bubbles at the interface of the implant and tissue. Among different methods used to improve the performance of the biodegradable Mg alloys to address these challenges, it appears that heat treatment is the most effective way to modify the microstructure and thus the corrosion behavior and mechanical properties without changing the composition or shape of the alloys. A desirable combination of corrosion and mechanical properties can be obtained through a precise control of the heat treatment parameters. In this report, the effects of different heat treatments (T4 and T6) on the microstructure, corrosion behavior, and mechanical properties of some of the most important heat-treatable biodegradable Mg alloys (Mg-Zn, Mg-Gd, Mg-Y, Mg-Nd, Mg-Al and Mg-Ag) are examined as well as new perspectives to enhance their clinical implementation.

可生物降解的镁 (Mg) 合金在组织工程应用中作为临时结构具有巨大的潜力。这种可降解的植入物不需要二次手术来移除。此外，它们与人体骨骼相当的机械性能，以及出色的生物相容性，使它们成为骨折治疗的合适候选者。尽管如此，仍然存在一些挑战。镁基合金在生理环境中的快速降解会导致完全组织愈合所需的机械支撑的丧失，并且还会导致氢气气泡在植入物和组织的界面处积聚。在用于提高可生物降解镁合金性能以应对这些挑战的不同方法中，热处理似乎是在不改变合金成分或形状的情况下改变微观结构以及腐蚀行为和机械性能的最有效方法。通过精确控制热处理参数可以获得理想的腐蚀和机械性能组合。在本报告中，不同热处理（T4 和 T6）对一些最重要的可热处理生物降解镁合金（Mg-Zn、Mg-Gd、Mg-Y、 Mg-Nd、Mg-Al 和 Mg-Ag) 进行了检查以及新的观点以增强其临床实施。通过精确控制热处理参数可以获得理想的腐蚀和机械性能组合。在本报告中，不同热处理（T4 和 T6）对一些最重要的可热处理生物降解镁合金（Mg-Zn、Mg-Gd、Mg-Y、 Mg-Nd、Mg-Al 和 Mg-Ag) 进行了检查以及新的观点以增强其临床实施。通过精确控制热处理参数可以获得理想的腐蚀和机械性能组合。在本报告中，不同热处理（T4 和 T6）对一些最重要的可热处理生物降解镁合金（Mg-Zn、Mg-Gd、Mg-Y、 Mg-Nd、Mg-Al 和 Mg-Ag) 进行了检查以及新的观点以增强其临床实施。