Desertification and salinization are both threats to the ecosystem services in inland river oases of arid regions. Previous studies focus on either desertification or salinization, and there is a lack of joint studies on the two issues. The essential cause of desertification in a transition zone is usually concentrated irrigation water use, which leads to shrink of the subsurface flow field of groundwater, decline of the groundwater level, and loss of groundwater supply to the vegetation. The salinization problem in an oasis area is mainly caused by the local excess groundwater in the oasis, referring to secondary salinization, which leads to salt migration with the groundwater level rise to form salt crystallization at the land surface. Thus, the processes of desertification and secondary salinization are connected, and the solutions to the two problems can be complementary, i.e., by transporting the excess groundwater in the local secondary salinization area to the transition zone area where water is scarce. This paper, taking Luocheng Irrigation District in the Heihe River Basin of northwestern China as an example, estimates 1.76–4.70 million m³ of excess groundwater that can be extracted in the salinized area. Using this amount of water through engineering regulation, it is estimated that the transition zone nearby the irrigation district, which is under desertification threat, can be restored with an area of 23–212 km². An engineering system is designed for coordinated groundwater regulation and the implementation with an experimental farm in the irrigation district is demonstrated.