Acyl fluorides are powerful synthons for acylation with wide application in the synthesis of valued compounds, especially peptides. Herein, a practical and catalyst-free method for the synthesis of acyl fluorides from aldehydes via C(sp²)–H fluorination is reported. This method enables the conversion of both aliphatic and aromatic aldehydes into acyl fluorides in good to excellent yields by visible-light under mild conditions in the absence of transition-metal and external photosensitizer. A variety of functional groups were well tolerated for this transformation. This green method provides a practical pathway to synthesize acyl fluorides under mild conditions.

酰基氟化物是强大的酰化合成子，广泛应用于合成有价值的化合物，尤其是多肽。在此，报道了一种通过C(sp ² )–H 氟化从醛类合成酰基氟的实用且无催化剂的方法。该方法能够在没有过渡金属和外部光敏剂的情况下，在温和条件下通过可见光将脂肪族和芳香族醛转化为酰基氟，产率从高到高。对于这种转变，各种功能组都具有良好的耐受性。这种绿色方法为在温和条件下合成酰基氟提供了一条实用途径。