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NiH-catalyzed asymmetric hydroalkynylation of α,β-unsaturated amides
Green Synthesis and Catalysis Pub Date : 2022-03-22 , DOI: 10.1016/j.gresc.2022.03.009 Yuanzheng Cheng , Zhuofan Gui , Ran Tao , You Wang , Shaolin Zhu
中文翻译:
NiH催化的α,β-不饱和酰胺的不对称加氢炔基化反应
更新日期:2022-03-22
Green Synthesis and Catalysis Pub Date : 2022-03-22 , DOI: 10.1016/j.gresc.2022.03.009 Yuanzheng Cheng , Zhuofan Gui , Ran Tao , You Wang , Shaolin Zhu
An enantioselective NiH-catalyzed hydroalkynylation of α,β-unsaturated amides is reported. A wide range of α,β-unsaturated amides and bromoalkynes are suitable substrates for this reaction, which proceeds under mild conditions, allowing access to a variety of enantioenriched chiral β-alkynyl amides. β,γ-Unsaturated amides can also be used as substrates and undergo the β-selective hydroalkynylation with a slightly lower enantiomeric excess.
中文翻译:
NiH催化的α,β-不饱和酰胺的不对称加氢炔基化反应
报道了α,β-不饱和酰胺的对映选择性 NiH 催化加氢炔基化反应。范围广泛的α,β-不饱和酰胺和溴代炔烃是该反应的合适底物,该反应在温和条件下进行,可以获得各种富含对映体的手性β-炔基酰胺。β,γ-不饱和酰胺也可用作底物,并以略低的对映体过量进行β-选择性加氢炔基化。