Abstract Trimethoprim drug (TMP) complexes of copper (II), cobalt (II), and nickel (II) were prepared and discussed by using elemental analysis (C, H, N analysis), magnetic, molar conductance, FTIR, Raman spectroscopy, electron spin resonance (ESR) and UV-vis spectroscopy analyses. TMP drug coordinated as a tridentate ligand towards the respected three metal ions through two nitrogen atoms of amino groups and nitrogen atom of pyrimidine ring which flanked between –NH2 groups, these assignments confirmed by spectroscopic, magnetic, ESR and thermogravimetric analyses with formulas [Cu(TMP)(H2O)3]Cl2, [Co(TMP)(H2O)3]Cl2 and [Ni(TMP) (H2O)]Cl2. Copper (II) and cobalt (II) complexes have an octahedral geometrical structure included one TMP molecule, three coordinated water molecules and two uncoordinated chlorine atoms while, nickel(II)–TMP complex has a tetrahedral geometric configuration that involved one TMP molecule, one coordinated water molecule and two uncoordinated chlorine atoms. The activation energies and other kinetic thermodynamic parameters were estimated based on the employed of the Coats-Redfern and Horowitz-Metzger equations. The nano–structured form of the synthesized TMP complexes was confirmed dependent on the transmission electron microscopy (TEM).

中文翻译：

---

甲氧苄啶药物三种新型过渡金属配合物的原位甲醇溶剂合成、光谱和热重表征

摘要 采用元素分析（C、H、N分析）、磁性、摩尔电导、FTIR、拉曼光谱、电子自旋共振 (ESR) 和紫外可见光谱分析。TMP 药物通过两个氨基的氮原子和位于 –NH2 基团之间的嘧啶环的氮原子作为三齿配体与三个金属离子配位，这些分配通过光谱、磁性、ESR 和热重分析证实，公式 [Cu( TMP)(H2O)3]Cl2、[Co(TMP)(H2O)3]Cl2 和 [Ni(TMP) (H2O)]Cl2。铜 (II) 和钴 (II) 配合物具有八面体几何结构，包括一个 TMP 分子、三个配位的水分子和两个未配位的氯原子，而，镍 (II)-TMP 配合物具有四面体几何构型，包括一个 TMP 分子、一个配位水分子和两个未配位的氯原子。基于使用 Coats-Redfern 和 Horowitz-Metzger 方程估计活化能和其他动力学热力学参数。合成的 TMP 复合物的纳米结构形式通过透射电子显微镜 (TEM) 得到证实。