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Stomach-affecting intestinal parasites as a precursor model of Pheretima posthuma treated with anthelmintic drug from Dodonaea viscosa Linn.
Green Processing and Synthesis ( IF 4.3 ) Pub Date : 2022-01-01 , DOI: 10.1515/gps-2022-0029
Rajesh Pandiyan 1 , Sumathi C. Samiappan 2 , Abimanyu Sugumaran 3 , Subpiramaniyam Sivakumar 4
Affiliation  

Abstract The preponderance of helminth contagions is constrained to tropical regions and can cause massive vulnerability to malnutrition, anemia, pneumonia, and eosinophilia. Many human parasitic diseases cause severe illness in endemic populations. The helminths transmitting through the gastro-intestinal tract may develop resistance to anthelmintic drugs. The phytotherapy, anthelmintic, and antimicrobial efficacy of Dodonaea viscosa leaf solvent extracts were examined. Phytochemical screening was carried out by ultraviolet (UV) and Fourier transform infrared spectroscopy (FTIR). The anthelmintic activity was performed against a South Indian earth worm as a model by measuring the paralytic time. The antibacterial activity was performed against Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, which stimulate the stomach helminths. Phytochemical screening revealed the presence of chemical compounds from the UV spectrum, and alkenes and aromatic compounds were confirmed by FTIR. Higher concentrations of the D. viscosa extract showed a rapid paralytic effect with a rapid death rate and histopathology. The zone-of-inhibition study indicated the potent antibacterial activity of the ethanolic and methanolic extracts of D. viscosa against different bacterial species. The current research revealed that D. viscosa has significant anthelmintic and antibacterial activities and it can be used for further elucidation and characterization.

中文翻译:

影响胃的肠道寄生虫作为 Pheretima posthuma 的前体模型,用来自 Dodonaea viscosa Linn 的驱虫药物治疗。

摘要 蠕虫传染的优势仅限于热带地区,并可能导致严重的营养不良、贫血、肺炎和嗜酸性粒细胞增多症。许多人类寄生虫病在流行人群中引起严重疾病。通过胃肠道传播的蠕虫可能对驱虫药物产生抗药性。检测了粘多糖叶溶剂提取物的植物疗法、驱虫和抗菌功效。通过紫外(UV)和傅里叶变换红外光谱(FTIR)进行植物化学筛选。通过测量麻痹时间对作为模型的南印度蚯蚓进行驱虫活性。对枯草芽孢杆菌、大肠杆菌、肺炎克雷伯菌和金黄色葡萄球菌具有抗菌活性,这会刺激胃蠕虫。植物化学筛选揭示了紫外光谱中化合物的存在,烯烃和芳香族化合物通过 FTIR 得到证实。较高浓度的 D. viscosa 提取物显示出快速的麻痹作用,具有快速的死亡率和组织病理学。抑制区研究表明 D. viscosa 的乙醇和甲醇提取物对不同细菌种类具有有效的抗菌活性。目前的研究表明,D. viscosa 具有显着的驱虫和抗菌活性,可用于进一步的阐明和表征。viscosa 提取物显示出快速的麻痹作用,具有快速的死亡率和组织病理学。抑制区研究表明 D. viscosa 的乙醇和甲醇提取物对不同细菌种类具有有效的抗菌活性。目前的研究表明,D. viscosa 具有显着的驱虫和抗菌活性,可用于进一步的阐明和表征。viscosa 提取物显示出快速的麻痹作用,具有快速的死亡率和组织病理学。抑制区研究表明 D. viscosa 的乙醇和甲醇提取物对不同细菌种类具有有效的抗菌活性。目前的研究表明,D. viscosa 具有显着的驱虫和抗菌活性,可用于进一步的阐明和表征。
更新日期:2022-01-01
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