Objective To create a nomogram based on transcutaneous bilirubin values (TCB) in first week of life for term and late preterm (>34 weeks) neonates. Methods and design Prospective longitudinal study. Setting Four tertiary-care teaching hospitals (one each in eastern and southern India, two in northern India) between February 2019 and March 2020. Participants A total of 2492 term and late preterm (>34 weeks) neonates. Intervention Bilirubin was measured by transcutaneous bilirubinometer (Drager JM-105, Germany) in all neonates in pre-specified times of the day, 12 hourly every day since birth till discharge between 48 and 72 h, and data were recorded in epochs of 6 hourly intervals. Post-discharge, all neonates were called for review in next 48 h. Outcome measures Primary—TCB in first week of life. Secondary—factors having significant association with significant hyperbilirubinaemia requiring phototherapy. Results Total of 2492 neonates (males 1303 and female 1189), with a total of 14 162 TCB recordings were analysed and mean hourly bilirubin (TCB) at hourly intervals till 120 h and then daily bilirubin values on Days 6 and 7 were tabulated. We have constructed hour-specific bilirubin nomogram with percentiles as per gestational age in term and near-term Indian neonates till 120 h of life. Amongst the known risk factors, delayed cord clamping, primipara and breastfeeding jaundice had significant association for hyperbilirubinaemia needing phototherapy. Conclusions We have created gestation-specific nomogram of TCB levels in 6 hourly intervals for the first 120 postnatal hours, obtained from a large predominantly breast fed healthy, term and near-term Indian neonates.

中文翻译：

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足月和晚期早产印度新生儿生命前 120 小时经皮胆红素的胎龄特异性列线图

目的 为足月和晚期早产儿（＞34 周）创建基于经皮胆红素值 (TCB) 的列线图。方法和设计 前瞻性纵向研究。设置 2019 年 2 月至 2020 年 3 月期间有四家三级护理教学医院（印度东部和南部各一家，印度北部两家）。参与者 共有 2492 名足月和晚期早产儿（>34 周）新生儿。干预 用经皮胆红素计（Drager JM-105，德国）在一天中预先指定的时间测量所有新生儿的胆红素，从出生后每天 12 小时到出院 48 至 72 小时之间，并以 6 小时的时间段记录数据间隔。出院后，所有新生儿都被要求在接下来的 48 小时内进行复查。结果测量 主要——生命第一周的 TCB。次要因素与需要光疗的显着高胆红素血症显着相关。结果 分析了总共 2492 名新生儿（男性 1303 名和女性 1189 名），总共 14 162 次 TCB 记录，并将每小时间隔的平均每小时胆红素 (TCB) 制成表格，直到 120 小时，然后将第 6 天和第 7 天的每日胆红素值制成表格。我们根据足月和近期印度新生儿的胎龄构建了小时特定的胆红素列线图，百分位数直到生命 120 小时。在已知的危险因素中，延迟脐带钳夹、初产妇和母乳喂养黄疸与需要光疗的高胆红素血症显着相关。结论 我们在产后前 120 小时内以 6 小时为间隔创建了 TCB 水平的妊娠特异性列线图，该列线图来自一个以母乳喂养为主的大型健康人，