Abstract Dermal substitutes provide a template for dermal regeneration and reconstruction. They constitutes an ideal clinical treatment for deep skin defects. However, rapid vascularization remains as a major hurdle to the development and application of dermal substitutes. Several bioactive factors play an important regulatory role in the process of angiogenesis and an understanding of the mechanism of achieving their effective delivery and sustained function is vital. Nanomaterials have great potential for tissue engineering. Effective delivery of bioactive factors (including growth factors, peptides and nucleic acids) by nanomaterials is of increasing research interest. This paper discusses the process of dermal substitute angiogenesis and the roles of related bioactive factors in this process. The application of nanomaterials for the delivery of bioactive factors to enhance angiogenesis and accelerate wound healing is also reviewed. We focus on new systems and approaches for delivering bioactive factors for enhancing angiogenesis in dermal substitutes.

中文翻译：

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用于递送生物活性因子以增强伤口愈合过程中真皮替代物血管生成的纳米材料

摘要 真皮替代品为真皮再生和重建提供了模板。它们构成了深层皮肤缺损的理想临床治疗方法。然而，快速血管化仍然是真皮替代品开发和应用的主要障碍。几种生物活性因子在血管生成过程中起着重要的调节作用，了解实现其有效传递和持续功能的机制至关重要。纳米材料在组织工程方面具有巨大潜力。通过纳米材料有效递送生物活性因子（包括生长因子、肽和核酸）引起了越来越多的研究兴趣。本文探讨了真皮替代血管生成的过程及相关生物活性因子在该过程中的作用。还回顾了纳米材料在递送生物活性因子以增强血管生成和加速伤口愈合方面的应用。我们专注于提供生物活性因子以增强真皮替代品中血管生成的新系统和方法。