Photoinduced charge transfer processes in diastereomers are currently being intensively studied as models for the binding of chiral drugs to chiral amino acid residues located in the active centers of enzymes and receptors. In this regard, direct detection of paramagnetic forms of diastereomers formed upon UV irradiation is of considerable interest. In the present study, we use photochemically induced dynamic electron polarization (photo-CIDEP) to detect paramagnetic particles resulting from UV irradiation of dyads containing the well-known NSAID ( R / S )-ketoprofen with various electron donors. The use of CIDEP allowed us to detect the triplet state of KP in all studied dyads in the solid state, as well as the product of intramolecular electron transfer in the dyad with tryptophan, namely, the biradical zwitterion (BZ) in solid and liquid states. The difference in the CIDEP spectra of the BZ of RS and SS diastereomers corresponds to the previously predicted based on the analysis of the effects of CIDNP (chemically induced dynamic nuclear polarization).

中文翻译：

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手性连接系统中的固态 Photo-CIDEP

目前正在深入研究非对映异构体中的光诱导电荷转移过程，作为手性药物与位于酶和受体活性中心的手性氨基酸残基结合的模型。在这方面，直接检测在紫外线照射下形成的顺磁性形式的非对映异构体具有相当大的意义。在本研究中，我们使用光化学诱导的动态电子极化 (photo-CIDEP) 来检测由含有众所周知的 NSAID (R / S)-酮洛芬和各种电子供体的二合体的紫外线照射产生的顺磁性粒子。CIDEP 的使用使我们能够检测所有研究的固态二元体中 KP 的三重态，以及与色氨酸在二元体中分子内电子转移的产物，即固态和液态的双自由基两性离子 (BZ) .