: Epilepsy is one of the chronic diseases seen in 1.0% of the world’s population. For the study of antiepileptic medications, a variety of approaches have been used extensively. These methods provide reliable, accurate and reproducible results. The available analytical methods for the determination of AEDs in API, biological fluids and pharmaceutical formulations are reviewed in this context. The drugs categorized under AEDs were studied for differentanalytical procedures, methods and systematically classified on the basis of their applications. The analytical instruments used for determination of AEDs include various chromatographic techniques such as High-performance liquid chromatography (HPLC), Ultra performance liquid chromatography (UPLC), Gas chromatography (GC) etc. and other techniques such as hyphenated, spectrophotometric, electrochemical analysis including UV, MS/MS, ECD, CLND, Fluorescence, colometric electrochemical detector (CED) are covered in this review. Supporting electrolyte, pH, panel, mobile phase, measuring or detection potential, sensitivity, and selectivity are all recorded as part of the analytical method formulation and validation process. This review is beneficial for various researchers for further study and advancement in research related to antiepileptic drugs.

中文翻译：

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综述：抗癫痫药物的最新分析应用

: 癫痫症是一种慢性病，全世界有 1.0% 的人口患病。对于抗癫痫药物的研究，已经广泛使用了多种方法。这些方法提供可靠、准确和可重现的结果。本文回顾了用于测定 API、生物体液和药物制剂中 AED 的可用分析方法。对归类为 AED 的药物进行了不同的分析程序、方法研究，并根据其应用进行了系统分类。用于测定 AEDs 的分析仪器包括各种色谱技术，如高效液相色谱 (HPLC)、超高效液相色谱 (UPLC)、气相色谱 (GC) 等，以及其他技术，如联用、分光光度法、本综述涵盖电化学分析，包括 UV、MS/MS、ECD、CLND、荧光、比色电化学检测器 (CED)。支持电解质、pH、面板、流动相、测量或检测电位、灵敏度和选择性都被记录为分析方法制定和验证过程的一部分。该综述有利于广大科研人员进一步研究和推进抗癫痫药物相关研究。