Background:Bisphenol A (BPA) derivatives monomers as resins are common componentsin dental restorative materials and materials used for orthodontic treatment. However, they are a sourcefor BP-A leakage, which can affect adult and child health as an endocrine disruptor.Objective:This study aimed to investigate the level of BPA leakage from four selected weights (0.1,0.2, 0.3, 0.4 mg) of five different resin combinations used in dental restorative materials.Method:The resin combinations were cured with light for 20 seconds, kept in 1 mL of acetonitrile, andsonicated for 30 minutes. Separation was achieved by using BEH C18 (1.7 μm, 2.1 x 100 mm) analyticalcolumn (Waters® Acquity UPLC) and a mobile phase composed of water and acetonitrile (68:32v/v). Moreover, Waters® Xevo G2-SQToF coupled with Waters® Acquity UPLC system with binarySolvent Manager (I-Class) via electrospray ionization (ESI) interface was used to confirm peaks identities.Results:BPA was detected in all resin combinations and in all selected sample weights. However, BPAwas below the limit of quantification (LOQ) in all selected weights of the Filtek Z350 XT UniversalRestorative System. The results show that BPA is still released from selected dental resin combinationsavailable in the market despite the general concern about its potential adverse effects.Conclusion:Nevertheless, the amounts of BPA were within the acceptable levels indicated by the U.S.Environmental Protection Agency and the U.S. Department of Health and Human Services NationalToxicology Program and represent a very small contribution to the total BPA exposure. The use of alternativematerials such as high-viscosity glass ionomers, inorganic biomaterials, and ceramic would beideal and healthier for adults and children.

中文翻译：

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不同基质牙科树脂基复合材料内分泌干扰物双酚A泄漏量的测定

背景：作为树脂的双酚A（BPA）衍生物单体是牙科修复材料和正畸治疗材料中的常见成分。然而，它们是 BP-A 泄漏的来源，作为内分泌干扰物会影响成人和儿童的健康。目的：本研究旨在调查四种选定重量（0.1、0.2、0.3、0.4 mg）的 BPA 泄漏水平。用于牙科修复材料的五种不同树脂组合。方法：将树脂组合光固化 20 秒，保存在 1 mL 乙腈中，超声处理 30 分钟。使用 BEH C18 (1.7 μm, 2.1 x 100 mm) 分析柱 (Waters® Acquity UPLC) 和由水和乙腈 (68:32v/v) 组成的流动相实现分离。而且，Waters® Xevo G2-SQToF 与 ​​Waters® Acquity UPLC 系统通过电喷雾电离 (ESI) 接口结合使用二元溶剂管理器 (I-Class) 来确认峰的同一性。结果：在所有树脂组合和所有选定的样品重量中均检测到 BPA . 但是，在 Filtek Z350 XT 通用修复系统的所有选定砝码中，BPA 均低于定量限 (LOQ)。结果表明，尽管人们普遍担心其潜在的不利影响，但市场上选择的牙科树脂组合中仍会释放出 BPA。健康和人类服务国家毒理学计划，对 BPA 总暴露量的贡献很小。