Background:Several analytical approaches for assessing anti-cancer drugs in pharmaceuticalformulations have been developed over the last few years. QbD plays an important role inestablishing accurate analytical methods to analyze anti-cancer compounds. Quality by Design hasbecome a risk analysis and a science-based strategy, implemented by experimental methods to optimizesystem output with known variables for data. The influence of highly complex and correlationsof input variables on the output reactions of pharmaceutical drugs and empirical approacheshave been widely used to explain the design of experiments.Objective:The efficiency of the anti-cancer drugs and their formulation in the various dosageforms has been made convenient with the help of QbD designs such as Plackett Burman, full factorialdesign, etc. QbD contains various steps, which help enhance and sustain the quality of thedrug in its dosage form.Conclusion:This review covers a basic, efficient, and accurate analytical approach technique usingQuality by Design for anti-cancer drugs. Thus, an outline of the experimental methods used inanti-cancer drugs was identified and discussed.

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抗癌药物的 QbD 方法 - 综述

背景：在过去几年中，已经开发了几种评估药物制剂中抗癌药物的分析方法。QbD 在建立准确的分析方法来分析抗癌化合物方面发挥着重要作用。质量源于设计已成为风险分析和基于科学的策略，通过实验方法实施，以优化具有已知数据变量的系统输出。输入变量的高度复杂性和相关性对药物输出反应的影响和经验方法已被广泛用于解释实验设计。目的：方便抗癌药物及其在各种剂型中的制剂效率借助 Plackett Burman、全因子设计等 QbD 设计。QbD 包含各种步骤，这有助于提高和维持剂型中药物的质量。结论：本综述涵盖了一种基本的、有效的和准确的分析方法技术，使用质量源于设计的抗癌药物。因此，确定并讨论了用于抗癌药物的实验方法的概要。