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Acute stress promotes brain network integration and reduces state transition variability
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2022-06-06 , DOI: 10.1073/pnas.2204144119
Rong Wang 1, 2 , Shanshan Zhen 3 , Changsong Zhou 2, 4 , Rongjun Yu 3
Affiliation  

Despite the prevalence of stress, how brains reconfigure their multilevel, hierarchical functional organization in response to acute stress remains unclear. We examined changes in brain networks after social stress using whole-brain resting-state functional MRI (fMRI) by extending our recently published nested-spectral partition method, which quantified the functional balance between network segregation and integration. Acute stress was found to shift the brain into a more integrated and less segregated state, especially in frontal-temporal regions. Stress also stabilized brain states by reducing the variability of dynamic transition between segregated and integrated states. Transition frequency was associated with the change of cortisol, and transition variability was correlated with cognitive control. Our results show that brain networks tend to be more integrated and less variable after acute stress, possibly to enable efficient coping.

中文翻译:

急性应激促进脑网络整合并降低状态转换变异性

尽管压力普遍存在,但大脑如何重新配置​​其多层次、分层的功能组织以应对急性压力仍不清楚。我们通过扩展我们最近发布的嵌套光谱分区方法,使用全脑静息状态功能 MRI (fMRI) 检查了社会压力后大脑网络的变化,该方法量化了网络隔离和整合之间的功能平衡。研究发现,急性压力会使大脑进入更加整合和分离程度更低的状态,尤其是在额颞区。压力还通过减少分离状态和整合状态之间动态转换的可变性来稳定大脑状态。转换频率与皮质醇的变化相关,转换变异性与认知控制相关。
更新日期:2022-06-06
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