3,4-Methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) are the main components of illicit stimulant drugs, also known as “ecstasy”, which belong to psychoactive medicine and tend to be increasingly abused among drug addicts worldwide. Herein, an electrochemical sensor based on molecularly imprinted polydopamine (MIP@PDA) was developed to detect MDA and MDMA using differential pulse voltammetry (DPV). An MIP film on a Au electrode was synthesized via electrochemical polymerization with the safe chemical DA as the polymerization monomer and the uncontrolled pharmaceutical intermediate 3,4-methylenedioxyphenethylamine (MDPEA) as the template molecule, which can provide a great quantity of specific binding sites and expand the practical application of the sensor. Due to the superior affinity of MIP@PDA to the target, the proposed sensor displayed excellent analytical performance, with LODs of 37 nM and 54 nM for the determination of MDA and MDMA, respectively. Additionally, this sensor presented suitable selectivity, stability, reproducibility and detection ability in practical urine samples, which suggested that it is a promising candidate as a rapid diagnostic method in drug investigations.

中文翻译：

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基于聚多巴胺的分子印迹电化学传感器用于高选择性测定摇头丸成分

3,4-亚甲基二氧苯丙胺（MDA）和3,4-亚甲基二氧甲基苯丙胺（MDMA）是非法兴奋剂药物的主要成分，也被称为“摇头丸”，属于精神药物，在世界范围内吸毒者中越来越多地滥用。在此，开发了一种基于分子印迹聚多巴胺 (MIP@PDA) 的电化学传感器，用于使用差分脉冲伏安法 (DPV) 检测 MDA 和 MDMA。通过在 Au 电极上合成 MIP 薄膜以安全的化学DA为聚合单体，不受控制的医药中间体3,4-亚甲二氧苯乙胺（MDPEA）为模板分子进行电化学聚合，可提供大量特异性结合位点，拓展了传感器的实际应用。由于 MIP@PDA 对靶标的优异亲和力，所提出的传感器显示出出色的分析性能，用于测定 MDA 和 MDMA 的 LOD 分别为 37 nM 和 54 nM。此外，该传感器在实际尿液样本中表现出合适的选择性、稳定性、重现性和检测能力，这表明它是一种很有前途的候选药物，可作为药物研究中的快速诊断方法。