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The Role of Cell-derived Microparticles in Cardiovascular Diseases: Current Concepts
Current Pharmaceutical Design ( IF 3.1 ) Pub Date : 2022-04-30 , DOI: 10.2174/1381612828666220429081555
Panagiota K Stampouloglou 1 , Gerasimos Siasos 1, 2 , Evanthia Bletsa 1 , Evangelos Oikonomou 1 , Georgia Vogiatzi 1 , Konstantinos Kalogeras 1 , Efstratios Katsianos 1 , Michael-Andrew Vavuranakis 1 , Nektarios Souvaliotis 1 , Manolis Vavuranakis 1
Affiliation  

: Cardiovascular disease remains the main cause of human morbidity and mortality in developed countries. Microparticles (MPs) are small vesicles originating from the cell membrane as a result of various stimuli and particularly of biological processes that constitute the pathophysiology of atherosclerosis, such as endothelial damage. They form vesicles that can transfer various molecules and signals to remote target cells without direct cell-to-cell interaction. Circulating microparticles have been associated with cardiovascular diseases. Therefore, many studies have been designed to further investigate the role of microparticles as biomarkers for diagnosis, prognosis, and disease monitoring. To this concept, the pro-thrombotic and atherogenic potential of platelets and endothelial-derived MPs have gained research interest, especially concerning accelerated atherosclerosis and triggering as well as prognosis of an acute coronary syndrome. MPs, especially those of endothelial origin, have been investigated in different clinical scenarios of heart failure and in association with left ventricular loading conditions. Finally, most cardiovascular risk factors present unique features in the circulating MPs population, highlighting their pathophysiologic link to cardiovascular disease progression. In this review article, we present a synopsis of the biogenesis and characteristics of microparticles, as well as the most recent data concerning their implication in cardiovascular settings.

中文翻译:

细胞衍生微粒在心血管疾病中的作用:当前概念

:心血管疾病仍然是发达国家人类发病率和死亡率的主要原因。微粒 (MP) 是由于各种刺激,特别是构成动脉粥样硬化病理生理学的生物过程(例如内皮损伤)而从细胞膜产生的小囊泡。它们形成囊泡,可以将各种分子和信号转移到远程靶细胞,而无需直接的细胞间相互作用。循环微粒与心血管疾病有关。因此,许多研究旨在进一步研究微粒作为生物标志物在诊断、预后和疾病监测中的作用。对于这个概念,血小板和内皮衍生的 MPs 的促血栓形成和致动脉粥样硬化的潜力已经引起了研究兴趣,特别是关于加速动脉粥样硬化和触发以及急性冠状动脉综合征的预后。MPs,尤其是内皮来源的 MPs,已经在心力衰竭的不同临床情况下以及与左心室负荷条件相关的情况下进行了研究。最后,大多数心血管危险因素在循环 MPs 人群中呈现出独特的特征,突出了它们与心血管疾病进展的病理生理学联系。在这篇评论文章中,我们简要介绍了微粒的生物发生和特征,以及有关它们在心血管环境中的影响的最新数据。已经在心力衰竭的不同临床情况下以及与左心室负荷条件相关的情况下进行了研究。最后,大多数心血管危险因素在循环 MPs 人群中呈现出独特的特征,突出了它们与心血管疾病进展的病理生理学联系。在这篇评论文章中,我们简要介绍了微粒的生物发生和特征,以及有关它们在心血管环境中的影响的最新数据。已经在心力衰竭的不同临床情况下以及与左心室负荷条件相关的情况下进行了研究。最后,大多数心血管危险因素在循环 MPs 人群中呈现出独特的特征,突出了它们与心血管疾病进展的病理生理学联系。在这篇评论文章中,我们简要介绍了微粒的生物发生和特征,以及有关它们在心血管环境中的影响的最新数据。
更新日期:2022-04-30
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