Nanozyme was considered as one of the most promising substitutes for antibiotics, due to the selective catalysis for pathogens. In this work, a high-antibacterial activity SOD-like nanozyme based on hybrid Ag/CeO₂ nanocomposite was facilely prepared by using an innovative approach of selective laser welding in liquid. This prepared nanozyme displayed a high antimicrobial effect against Staphylococcus aureus under visible light illumination, the sterilization rate as high as 82.4%, which was 2.93 and 2.99 times higher than those of pure Ag and pure CeO₂, respectively. The enhanced antibacterial activity was attributed to the anchoring of Ag nanospheres on the surface of CeO₂ nanosheets, which induced the reduction of CeO₂ bandgap and boosted the visible light harvesting. Therefore, the charge carriers can be effectively stimulated to produce abundant reactive oxygen species on the Ag/CeO₂ nanocomposite via a SOD-like route. This work demonstrated a facile strategy for the preparation of high-antibacterial activity nanozyme, giving it great potential for scalable application in the biomedical and pharmaceutical industry.

由于对病原体具有选择性催化作用，纳米酶被认为是最有前途的抗生素替代品之一。在这项工作中，通过使用液体中选择性激光焊接的创新方法，轻松制备了一种基于杂化 Ag/CeO ₂纳米复合材料的高抗菌活性类 SOD 纳米酶。所制备的纳米酶在可见光照射下对金黄色葡萄球菌具有很强的抗菌作用，杀菌率高达82.4%，分别是纯Ag和纯CeO ₂的2.93和2.99倍。_{增强的抗菌活性归因于 Ag 纳米球在 CeO 2}纳米片表面的锚定，这诱导了 CeO ₂的还原带隙并促进了可见光的收集。因此，可以有效地激发载流子通过类SOD途径在Ag/CeO _{2纳米复合材料上产生丰富的活性氧。}这项工作展示了一种制备高抗菌活性纳米酶的简便策略，使其在生物医学和制药工业中具有巨大的可扩展应用潜力。