Secondary involvement of the prostate by urothelial or hematolymphoid neoplasms is relatively common and well-described. In contrast, less is known about the clinicopathologic spectrum of secondary solid tumors of the prostate of nonurothelial origin. This study evaluated a series of secondary nonurothelial solid tumors of the prostate diagnosed at 21 institutions. Eighty-five patients with a median age at diagnosis of 64 years were included. Sixty-two patients had clinically manifest disease (62/85, 73%), 10 were diagnosed incidentally (10/85, 12%), and 13 (13/85, 15%) had no detailed clinical data available about symptomatology at presentation. Among patients with clinically manifest disease, the most common symptoms and signs were lower urinary tract symptoms (either obstructive of irritative; 36/62, 58%), abdominal or pelvic pain or discomfort (16/62, 26%), and hematuria (12/62, 19%). Metastasis and direct invasion occurred at roughly similar frequencies (47% vs. 42%) in this series, and in 11% of the cases, the mechanism of spread to the prostate was unclear/uncertain. Overall, among tumors with confirmed sites of origin, the most common primary sites were gastrointestinal tract (53/85, 62%), lung (9/85, 11%), skin (6/85, 7%), and testis (4/85, 5%). Among metastases, the most common tumor types were lung carcinomas (9/40, 23%), colorectal adenocarcinomas (7/40, 18%), melanoma (6/40, 15%), and germ cell tumors (6/40, 15%). This study demonstrated that secondary involvement of the prostate by solid tumors of nonurothelial origin is commonly symptomatic and that the most frequent sites of origin are the gastrointestinal tract, lung, skin, and testis. These findings are worth considering when lesions with unusual cytomorphology and/or architecture are encountered in prostate specimens.

尿路上皮或血淋巴肿瘤对前列腺的继发性受累相对常见且已得到充分描述。相比之下，对非尿路上皮起源的继发性前列腺实体瘤的临床病理学谱知之甚少。本研究评估了在 21 个机构诊断出的一系列继发性非尿路上皮性前列腺实体瘤。纳入诊断时中位年龄为 64 岁的 85 名患者。62 名患者有临床表现（62/85, 73%），10 名被偶然诊断（10/85, 12%），13 名（13/85, 15%）在就诊时没有关于症状学的详细临床数据. 在有临床表现疾病的患者中，最常见的症状和体征是下尿路症状（阻塞性或刺激性；36/62，58%），腹部或骨盆疼痛或不适 (16/62, 26%) 和血尿 (12/62, 19%)。在该系列中，转移和直接侵袭的发生率大致相似（47% 对 42%），并且在 11% 的病例中，扩散到前列腺的机制尚不清楚/不确定。总体而言，在确定原发部位的肿瘤中，最常见的原发部位是胃肠道（53/85, 62%）、肺（9/85, 11%）、皮肤（6/85, 7%）和睾丸（ 4/85，5%）。在转移灶中，最常见的肿瘤类型是肺癌（9/40, 23%）、结直肠腺癌（7/40, 18%）、黑色素瘤（6/40, 15%）和生殖细胞肿瘤（6/40, 15%）。这项研究表明，非尿路上皮起源的实体瘤继发性侵犯前列腺通常是有症状的，最常见的起源部位是胃肠道、肺、皮肤和睾丸。