当前位置: X-MOL 学术Nat. Rev. Gastroenterol. Hepatol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mechanisms and pathophysiology of Barrett oesophagus
Nature Reviews Gastroenterology & Hepatology ( IF 65.1 ) Pub Date : 2022-06-07 , DOI: 10.1038/s41575-022-00622-w
Rhonda F Souza 1, 2 , Stuart J Spechler 1, 2
Affiliation  

Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose individuals to cancer development lines a portion of the distal oesophagus, is the only known precursor of oesophageal adenocarcinoma, the incidence of which has increased profoundly over the past several decades. Most evidence suggests that Barrett oesophagus develops from progenitor cells at the oesophagogastric junction that proliferate and undergo epithelial–mesenchymal transition as part of a wound-healing process that replaces oesophageal squamous epithelium damaged by gastroesophageal reflux disease (GERD). GERD also seems to induce reprogramming of key transcription factors in the progenitor cells, resulting in the development of the specialized intestinal metaplasia that is characteristic of Barrett oesophagus, probably through an intermediate step of metaplasia to cardiac mucosa. Genome-wide association studies suggest that patients with GERD who develop Barrett oesophagus might have an inherited predisposition to oesophageal metaplasia and that there is a shared genetic susceptibility to Barrett oesophagus and to several of its risk factors (such as GERD, obesity and cigarette smoking). In this Review, we discuss the mechanisms, pathophysiology, genetic predisposition and cells of origin of Barrett oesophagus, and opine on the clinical implications and future research directions.



中文翻译:

Barrett 食管的机制和病理生理学

Barrett 食管是唯一已知的食管腺癌前体,其中化生的柱状粘膜可使个体易患癌症,是食管腺癌的唯一已知前体,其发病率在过去几十年中急剧增加。大多数证据表明,Barrett 食管起源于食管胃交界处的祖细胞,这些祖细胞增殖并经历上皮-间质转化,作为伤口愈合过程的一部分,该过程替代了因胃食管反流病 (GERD) 受损的食管鳞状上皮。GERD 似乎还诱导祖细胞中关键转录因子的重编程,导致巴雷特食管特有的特殊肠化生的发展,可能通过化生到心脏粘膜的中间步骤。全基因组关联研究表明,患有 Barrett 食管的 GERD 患者可能具有食管化生的遗传易感性,并且对 Barrett 食管及其几个危险因素(如 GERD、肥胖和吸烟)存在共同的遗传易感性. 在这篇综述中,我们讨论了 Barrett 食管的机制、病理生理学、遗传易感性和起源细胞,并就其临床意义和未来研究方向发表了看法。全基因组关联研究表明,患有 Barrett 食管的 GERD 患者可能具有食管化生的遗传易感性,并且对 Barrett 食管及其几个危险因素(如 GERD、肥胖和吸烟)存在共同的遗传易感性. 在这篇综述中,我们讨论了 Barrett 食管的机制、病理生理学、遗传易感性和起源细胞,并就其临床意义和未来研究方向发表了看法。全基因组关联研究表明,患有 Barrett 食管的 GERD 患者可能具有食管化生的遗传易感性,并且对 Barrett 食管及其几个危险因素(如 GERD、肥胖和吸烟)存在共同的遗传易感性. 在这篇综述中,我们讨论了 Barrett 食管的机制、病理生理学、遗传易感性和起源细胞,并就其临床意义和未来研究方向发表了看法。

更新日期:2022-06-07
down
wechat
bug