Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation, the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional sutures. In the present work, degradable magnesium (Mg) alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4–0 absorbable suture as control. The shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4, 8, and 12 weeks after operation. The Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to failure. Gross observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture groups. In the histological analysis, for Mg alloy suture groups, chondrocytes appear to proliferate at 4 weeks postoperatively, and the tendon-bone interface showed an orderly structural transition zone at 8 weeks postoperatively. The collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed, where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous enthesis. In vivo degradation of the magnesium alloy wire was completed within 12 weeks. The results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

尽管使用缝合线修复经骨肩袖撕裂已被广泛接受用于腱骨固定，但传统缝合线仍难以实现纤维软骨附着点再生。在目前的工作中，将可降解镁（Mg）合金丝应用于大鼠急性肩袖撕裂模型中的冈上肌腱，以 Vicryl Plus 4-0 可吸收缝线作为对照。肩关节肱骨-冈上肌腱复合体标本分别于术后 4、8 和 12 周取回。镁合金缝合线组在极限失效载荷方面表现出更好的生物力学性能。大体观察表明，在 Mg 合金缝线和 Vicryl 缝线组中，肌腱 - 骨界面处瘢痕组织的增生反应随着时间的推移逐渐减轻。在组织学分析中，镁合金缝线组术后4周软骨细胞出现增殖现象，术后8周肌腱-骨界面呈现有序的结构过渡区。胶原纤维趋于排列，腱-骨联锁结构明显形成，未矿化纤维软骨向矿化纤维软骨过渡的结构更接近天然纤维软骨附着点。镁合金丝的体内降解在 12 周内完成。结果表明，镁合金丝有望作为可降解缝合线，在肩袖修复中具有促进纤维软骨界面再生的潜力。术后8周肌腱-骨界面呈现有序的结构过渡区。胶原纤维趋于排列，腱-骨联锁结构明显形成，未矿化纤维软骨向矿化纤维软骨过渡的结构更接近天然纤维软骨附着点。镁合金丝的体内降解在 12 周内完成。结果表明，镁合金丝有望作为可降解缝合线，在肩袖修复中具有促进纤维软骨界面再生的潜力。术后8周肌腱-骨界面呈现有序的结构过渡区。胶原纤维趋于排列，腱-骨联锁结构明显形成，未矿化纤维软骨向矿化纤维软骨过渡的结构更接近天然纤维软骨附着点。镁合金丝的体内降解在 12 周内完成。结果表明，镁合金丝有望作为可降解缝合线，在肩袖修复中具有促进纤维软骨界面再生的潜力。其中从未矿化的纤维软骨到矿化的纤维软骨的过渡结构更接近天然纤维软骨附着点。镁合金丝的体内降解在 12 周内完成。结果表明，镁合金丝有望作为可降解缝合线，在肩袖修复中具有促进纤维软骨界面再生的潜力。其中从未矿化的纤维软骨到矿化的纤维软骨的过渡结构更接近天然纤维软骨附着点。镁合金丝的体内降解在 12 周内完成。结果表明，镁合金丝有望作为可降解缝合线，在肩袖修复中具有促进纤维软骨界面再生的潜力。