Background

Surgical scars seriously affect a patient’s quality of life, and they have a strong impact on individuals. Many studies have reported the results of using fractional carbon dioxide (CO₂) laser to treat surgical scars and have generally found it to be effective.

Objectives

We conducted a meta-analysis with the objective of evaluating and proving the efficacy of fractional CO₂ laser therapy for surgical scars.

Methods

We performed a search of databases including PubMed, Web of Science, Embase and the Cochrane Library. The outcomes of the meta-analysis were overall scores on the Vancouver Scar Scale (VSS) and its four dimensions (pigmentation, vascularity, pliability and height). Statistical analysis was performed using RevMan 5.4 software.

Results

A total of ten studies were included in this meta-analysis, including six randomized controlled trials (RCTs) and four nonrandomized controlled trials (N-RCTs). In the meta-analysis of RCTs and N-RCTs, similar results were obtained, and fractional CO₂ laser irradiation significantly decreased VSS scores (P < 0.00001). In addition, fractional CO₂ laser irradiation also had a significant effect on scores on the pigmentation (P = 0.08), vascularity (P = 0.001), flexibility (P = 0.005) and height (P = 0.008) dimensions. Except for mild pain during treatment and temporary erythema after treatment, most patients had no obvious adverse reactions.

Conclusion

Our study found that fractional CO₂ laser exhibits excellent efficacy and safety in terms of surgical scar treatment. Thus, we hope it becomes more widely available to patients with surgical scars.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

中文翻译：

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点阵二氧化碳激光治疗手术疤痕的疗效：系统回顾和荟萃分析

背景

手术疤痕严重影响患者的生活质量，对个人的影响也很大。_{许多研究报告了使用点阵二氧化碳 (CO 2} ) 激光治疗手术疤痕的结果，并且普遍认为它是有效的。

目标

我们进行了一项荟萃分析，目的是评估和证明点阵 CO ₂激光治疗手术疤痕的疗效。

方法

我们对数据库进行了搜索，包括 PubMed、Web of Science、Embase 和 Cochrane 图书馆。荟萃分析的结果是温哥华疤痕量表 (VSS) 及其四个维度（色素沉着、血管分布、柔韧性和高度）的总分。使用 RevMan 5.4 软件进行统计分析。

结果

本荟萃分析共纳入 10 项研究，包括 6 项随机对照试验 (RCT) 和 4 项非随机对照试验 (N-RCT)。在 RCT 和 N-RCT 的荟萃分析中，获得了相似的结果，点阵 CO ₂激光照射显着降低了 VSS 评分（P < 0.00001）。此外，点阵 CO _{2激光照射也对色素沉着 (} P = 0.08)、血管分布 ( P = 0.001)、柔韧性 ( P = 0.005) 和身高 ( P = 0.008) 方面的评分有显着影响。除治疗过程中轻微疼痛和治疗后出现暂时性红斑外，大部分患者无明显不良反应。

结论

我们的研究发现，点阵 CO ₂激光在手术疤痕治疗方面具有出色的疗效和安全性。因此，我们希望它能更广泛地用于有手术疤痕的患者。

证据等级 III

该期刊要求作者为每篇文章分配一定程度的证据。有关这些循证医学评级的完整说明，请参阅目录或在线作者须知 www.springer.com/00266。