Objective: The study was designed to determine (1) the pharmacokinetic (PK) profile of dexmethylphenidate (d-MPH) after oral administration of three dosage strengths of a new treatment containing d-MPH and a novel prodrug, serdexmethylphenidate (SDX); (2) the dose proportionality of the different SDX/d-MPH dosages; and (3) the steady-state PK profile of d-MPH and SDX after multiple dosing of SDX/d-MPH.

中文翻译：

---

Serdexmethylphenidate/Dexmethylphenidate 的剂量比例和稳态药代动力学，一种治疗注意力缺陷/多动障碍的新型前药组合

目的：本研究旨在确定 (1) 口服给药三种剂量强度的包含 d-MPH 和新型前药哌醋甲酯 (SDX) 的新疗法后，右旋哌醋甲酯 (d-MPH) 的药代动力学 (PK) 曲线；(2)不同SDX/d-MPH剂量的剂量比例；(3) 多次给药 SDX/d-MPH 后 d-MPH 和 SDX 的稳态 PK 曲线。