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Obesity in late adolescence and incident type 1 diabetes in young adulthood
Diabetologia ( IF 8.2 ) Pub Date : 2022-06-05 , DOI: 10.1007/s00125-022-05722-5
Inbar Zucker 1, 2 , Yair Zloof 1, 3 , Aya Bardugo 3, 4 , Avishai M Tsur 1, 3, 5 , Miri Lutski 1, 2 , Yaron Cohen 3, 4 , Tali Cukierman-Yaffe 1, 6 , Noga Minsky 1, 6 , Estela Derazne 7 , Dorit Tzur 3, 4 , Cheli Melzer Cohen 1, 8 , Orit Pinhas-Hamiel 7, 8, 9 , Gabriel Chodick 1, 8 , Itamar Raz 10 , Arnon Afek 7, 11 , Hertzel C Gerstein 12 , Amir Tirosh 6, 7 , Gilad Twig 1, 3, 4, 6
Affiliation  

Aims/hypothesis

Studies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood.

Methods

All Israeli adolescents, ages 16–19 years, undergoing medical evaluation in preparation for mandatory military conscription between January 1996 and December 2016 were included for analysis unless they had a history of dysglycaemia. Data were linked with information about adult onset of type 1 diabetes in the Israeli National Diabetes Registry. Weight and height were measured at study entry. Cox proportional models were applied, with BMI being analysed both as a categorical and as a continuous variable.

Results

There were 777 incident cases of type 1 diabetes during 15,819,750 person-years (mean age at diagnosis 25.2±3.9 years). BMI was associated with incident type 1 diabetes. In a multivariable model adjusted for age, sex and sociodemographic variables, the HRs for type 1 diabetes were 1.05 (95% CI 0.87, 1.27) for the 50th–74th BMI percentiles, 1.41 (95% CI 1.11, 1.78) for the 75th–84th BMI percentiles, 1.54 (95% CI 1.23, 1.94) for adolescents who were overweight (85th–94th percentiles), and 2.05 (95% CI 1.58, 2.66) for adolescents with obesity (≥95th percentile) (reference group: 5th–49th BMI percentiles). One increment in BMI SD was associated with a 25% greater risk for incidence of type 1 diabetes (HR 1.25, 95% CI 1.17, 1.32).

Conclusions

Excessively high BMI in otherwise healthy adolescents is associated with increased risk for incident type 1 diabetes in early adulthood.

Graphical abstract



中文翻译:

青春期后期的肥胖和成年早期发生的 1 型糖尿病

目标/假设

针对儿童的研究报告称,BMI 增加与患 1 型糖尿病的风险之间存在关联,但青春期后期的证据有限。我们研究了青春期后期 BMI 与青年期 1 型糖尿病发病率之间的关联。

方法

1996 年 1 月至 2016 年 12 月期间,所有 16 至 19 岁的以色列青少年都接受了医学评估,为强制征兵做准备,除非他们有血糖异常病史,否则他们都被纳入分析。数据与以色列国家糖尿病登记处有关成人 1 型糖尿病发病的信息相关联。在研究开始时测量体重和身高。应用 Cox 比例模型,将 BMI 作为分类变量和连续变量进行分析。

结果

在 15,819,750 人年中,有 777 例 1 型糖尿病发病病例(诊断时的平均年龄为 25.2±3.9 岁)。BMI 与 1 型糖尿病的发生有关。在根据年龄、性别和社会人口统计学变量进行调整的多变量模型中,1 型糖尿病的 HR 在第 50-74 个 BMI 百分位处为 1.05 (95% CI 0.87, 1.27),在第 75-75 个 BMI 百分位处为 1.41 (95% CI 1.11, 1.78)。 BMI 第 84 个百分位数,超重青少年(第 85-94 个百分位数)为 1.54(95% CI 1.23,1.94),肥胖青少年(≥ 95 个百分位数)为 2.05(95% CI 1.58,2.66)(参考组:第 5-94 个百分位数) BMI 第 49 个百分位数)。BMI SD 每增加一分,1 型糖尿病的发病风险就会增加 25%(HR 1.25,95% CI 1.17,1.32)。

结论

在其他方面健康的青少年中,BMI 过高与成年早期发生 1 型糖尿病的风险增加有关。

图形概要

更新日期:2022-06-06
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