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Identifying Migraine Phenotype Post Traumatic Headache (MPTH) to Guide Overall Recovery From Traumatic Brain Injury
Journal of Child Neurology ( IF 1.9 ) Pub Date : 2022-06-03 , DOI: 10.1177/08830738221100327
Susan K. Klein, Cynthia B. Brown, Sarah Ostrowski-Delahanty, David Bruckman, M. Cristina Victorio

Objective: The primary aim of this study is to develop an easy way to identify migraine phenotype posttraumatic headache (MPTH) in children with traumatic brain injury, to treat headache in traumatic brain injury effectively, and to promote faster recovery from traumatic brain injury symptoms overall. Methods: We evaluated youth aged 7-20 years in a pediatric neurology traumatic brain injury (TBI) clinic, assigning a migraine phenotype for post-traumatic headache (MPTH) at the initial visit with the 3-item ID Migraine Screener. We stratified the sample by early (≤6 weeks) and late (>6 weeks) presenters, using days to recovery from concussion symptoms as the primary outcome variable. Results: 397 youth were assessed; 54% were female. Median age was 15.1 years (range 7.0-20.4 years), and 34% of the sample had sports-related injuries. Migraine phenotype for posttraumatic headache (MPTH) was assigned to 56.1% of those seen within 6 weeks of traumatic brain injury and 50.7% of those seen after the 6-week mark. Irrespective of whether they were early or late presenters to our clinic, patients with migraine phenotype (MPTH) took longer to recover from traumatic brain injury than those with posttraumatic headache (PTH) alone. Log rank test indicated that the survival (ie, recovery) distributions between those with migraine phenotype posttraumatic headache (MPTH) and those with posttraumatic headache (PTH) were statistically different, χ2(3) = 50.186 (P < .001). Conclusions: Early identification of migraine phenotype posttraumatic headache (MPTH) following concussion can help guide more effective treatment of headache in traumatic brain injury and provide a road map for the trajectory of recovery from traumatic brain injury symptoms. It will also help us understand better the mechanisms that underlie conversion to persistent posttraumatic headache and chronic migraine after traumatic brain injury.



中文翻译:

识别创伤后头痛 (MPTH) 的偏头痛表型以指导创伤性脑损伤的整体恢复

目的:本研究的主要目的是开发一种简单的方法来识别创伤性脑损伤儿童的偏头痛表型创伤后头痛 (MPTH),有效治疗创伤性脑损伤中的头痛,并促进从整体上更快地从创伤性脑损伤症状中恢复。 . 方法:我们在儿科神经外伤性脑损伤 (TBI) 诊所评估了 7-20 岁的青年,在初次就诊时使用 3 项 ID 偏头痛筛查器为创伤后头痛 (MPTH) 分配偏头痛表型。我们将样本按早期(≤6 周)和晚期(>6 周)呈现者进行分层,使用从脑震荡症状中恢复的天数作为主要结果变量。结果:对 397 名青年进行了评估;54% 是女性。中位年龄为 15.1 岁(范围 7.0-20.4 岁),34% 的样本有运动相关损伤。创伤后头痛 (MPTH) 的偏头痛表型被分配给在创伤性脑损伤 6 周内观察到的患者中的 56.1% 和在 6 周标记后观察到的患者中的 50.7%。无论他们是我们诊所的早期或晚期就诊者,偏头痛表型 (MPTH) 患者从创伤性脑损伤中恢复所需的时间比仅患有创伤后头痛 (PTH) 的患者要长。对数秩检验表明,偏头痛表型创伤后头痛 (MPTH) 和创伤后头痛 (PTH) 患者的生存(即恢复)分布存在统计学差异,χ2(3) = 50.186 ( P  < .001)。结论:早期识别脑震荡后偏头痛表型创伤后头痛 (MPTH) 有助于指导更有效地治疗创伤性脑损伤中的头痛,并为创伤性脑损伤症状的恢复轨迹提供路线图。它还将帮助我们更好地了解创伤性脑损伤后转变为持续性创伤后头痛和慢性偏头痛的机制。

更新日期:2022-06-05
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