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Global Longitudinal Strain for the Early Detection of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-analysis
Clinical Oncology ( IF 3.4 ) Pub Date : 2022-05-27 , DOI: 10.1016/j.clon.2022.05.001
L D Cocco 1 , A F Chiaparini 1 , M A L Saffi 2 , T L L Leiria 1
Affiliation  

Aims

Left ventricular ejection fraction is used to monitor patients undergoing cardiotoxic chemotherapy. A decrease in left ventricular ejection fraction represents a relatively late stage of systolic involvement. Global longitudinal strain has been studied to detect early changes in left ventricular myocardial contractile function. The aim of the present study was to evaluate the global longitudinal strain measurement in the early detection of cardiotoxicity induced by cardiotoxic chemotherapeutic agents.

Materials and methods

A study search strategy based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was carried out to report systematic reviews. A search on PubMed, EMBASE, Web of Science and SCOPUS was carried out using the following keywords: ‘echocardiography’ and ‘cardiotoxicity’ and their variations, without language or date restrictions (until March 2021).

Results

In total, 4873 articles were identified for title and abstract analysis. The systematic review included 10 studies comprising 661 patients with cancer, including mainly breast cancer and haematological malignancies, mainly treated with anthracyclines. The meta-analysis included four studies: patients with cardiotoxicity showed a reduction in strain, compared with baseline, 14.13% greater than patients without cardiotoxicity (95% confidence interval 5.07–23.19; P < 0.01). No heterogeneity was observed between studies (I2 = 0).

Conclusion

The meta-analysis showed that strain is a tool with proper predictive capacity for the detection of cardiotoxicity.



中文翻译:

早期检测化疗引起的心脏毒性的全球纵向应变:系统评价和荟萃分析

目标

左心室射血分数用于监测接受心脏毒性化疗的患者。左心室射血分数的降低代表收缩期受累的相对晚期。已经研究了全局纵向应变以检测左心室心肌收缩功能的早期变化。本研究的目的是评估全球纵向应变测量在早期检测由心脏毒性化学治疗剂引起的心脏毒性中的作用。

材料和方法

基于系统评价和元分析的首选报告项目 (PRISMA) 的研究搜索策略用于报告系统评价。使用以下关键字在 PubMed、EMBASE、Web of Science 和 SCOPUS 上进行了搜索:“超声心动图”和“心脏毒性”及其变体,没有语言或日期限制(直到 2021 年 3 月)。

结果

总共确定了 4873 篇文章进行标题和摘要分析。系统评价包括 10 项研究,包括 661 名癌症患者,主要包括乳腺癌和血液系统恶性肿瘤,主要使用蒽环类药物治疗。荟萃分析包括四项研究:与基线相比,有心脏毒性的患者应变减少,比没有心脏毒性的患者高 14.13%(95% 置信区间 5.07-23.19;P < 0.01)。研究之间未观察到异质性(I2 = 0)。

结论

荟萃分析表明,应变是一种具有适当预测能力的工具,可用于检测心脏毒性。

更新日期:2022-05-27
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