So far, cloaking materials with platelet membranes have been widely studied, mainly focused on covering nanosized materials but rarely forwarded to dressing large-scale materials. Herein, a platelet-membrane coating (PMC) constructed on the surface of a macroscopic device is reported, driven by the spontaneous fusion of platelet-membrane vesicles (PMVs) with a negatively charged superhydrophilic surface. The coating contains not only phospholipids but also a variety of functional proteins of the platelet membrane, which is a further leap compared with surface-modification strategies of imitating cell-membrane structure with inert synthetic amphiphilic molecules. The preservation of membrane proteins by dressing PMC endows the surface of macroscopic devices with bioactivity. The implantation of vascular stents covered with PMC demonstrates the potential to address the desired biointerface properties, such as thromboprotection and anti-inflammation, and promote re-endothelialization. Overall, dressing large-scale blood-contacting materials with PMC provides a multifunctional biointerface by naturally preserved membrane proteins.

迄今为止，用血小板膜遮盖材料的研究较多，主要集中在纳米材料的遮盖上，而很少转向大尺寸材料的遮盖。本文报道了一种在宏观装置表面上构建的血小板膜涂层 (PMC)，它是由血小板膜囊泡 (PMV) 与带负电荷的超亲水表面的自发融合驱动的。该涂层不仅含有磷脂，还含有血小板膜的多种功能蛋白，与惰性合成两亲分子模拟细胞膜结构的表面修饰策略相比，这是一个进一步的飞跃。通过包扎PMC对膜蛋白的保存赋予了宏观装置表面生物活性。植入 PMC 覆盖的血管支架展示了解决所需生物界面特性的潜力，例如血栓保护和抗炎，并促进再内皮化。总体而言，用 PMC 包扎大型血液接触材料通过天然保存的膜蛋白提供多功能生物界面。