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Programmable multicellular and spatially patterned organoids: A one-pot strategy
Matter ( IF 18.9 ) Pub Date : 2022-06-01 , DOI: 10.1016/j.matt.2022.04.026
Qimanguli Saiding, Xinliang Chen, Wenguo Cui

The simultaneous differentiation of human-induced pluripotent stem cells (hiPSCs) into different cell types is the basis for obtaining organoids and tissues with complex cell components, structures, and functions. Lewis and colleagues' latest work published in Nature Biomedical Engineering presented a new one-pot orthogonally differentiation strategy combined with a multi-material 3D bioprinting method to generate programmatic patterned organoids and bioprinted tissues. This approach will provide a new roadmap to developing engineered tissues for extensive biomedical applications.



中文翻译:

可编程多细胞和空间图案类器官:一锅法

人诱导多能干细胞(hiPSCs)同时分化为不同细胞类型是获得具有复杂细胞成分、结构和功能的类器官和组织的基础。Lewis 及其同事在 Nature Biomedical Engineering 上发表的最新工作提出了一种新的单锅正交分化策略,结合多材料 3D 生物打印方法来生成程序化的图案化类器官和生物打印组织。这种方法将为开发用于广泛生物医学应用的工程组织提供新的路线图。

更新日期:2022-06-03
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