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The roles of polymers in mRNA delivery
Matter ( IF 18.9 ) Pub Date : 2022-06-01 , DOI: 10.1016/j.matt.2022.03.006
Pei Huang, Hongzhang Deng, Yongfeng Zhou, Xiaoyuan Chen

mRNA therapy, which possesses distinctive advantages over DNA and protein-based therapies, has immense potential for diverse applications, including mRNA vaccines, protein-replacement therapy, gene editing, and cell reprogramming. Nevertheless, successful mRNA therapy requires the production of stable mRNA with minimal immunogenicity and establishment of a safe and effective delivery system. Polymeric mRNA delivery vehicles have attracted great interest recently and developed quickly rendered by endless synthetic capability, versatile structure, and robust stability. In this review, firstly, we summarize the development of polymeric nanocarriers for mRNA delivery. Secondly, the approaches to enhance mRNA transfection efficiency are emphatically discussed, involving tuning the polymer structure, engineering the polymeric nanoparticles, and improving efficiency in the mRNA delivery process. Finally, conclusions and perspectives are proposed for mRNA therapy, especially regarding acceleration of their clinical translation. We believe that introduction of mRNA will lead to next-generation promising techniques for disease prevention and treatment in the near future.



中文翻译:

聚合物在 mRNA 传递中的作用

与基于 DNA 和蛋白质的疗法相比,mRNA 疗法具有独特的优势,在多种应用中具有巨大的潜力,包括 mRNA 疫苗、蛋白质替代疗法、基因编辑和细胞重编程。然而,成功的 mRNA 治疗需要产生具有最小免疫原性的稳定 mRNA,并建立安全有效的递送系统。聚合物 mRNA 递送载体最近引起了极大的兴趣,并通过无限的合成能力、多功能的结构和强大的稳定性迅速发展。在这篇综述中,我们首先总结了用于 mRNA 递送的聚合物纳米载体的发展。其次,重点讨论了提高 mRNA 转染效率的方法,包括调整聚合物结构、工程化聚合物纳米颗粒、并提高 mRNA 递送过程的效率。最后,提出了 mRNA 治疗的结论和观点,特别是在加速其临床转化方面。我们相信,在不久的将来,引入 mRNA 将导致下一代有前途的疾病预防和治疗技术。

更新日期:2022-06-03
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