Fibroblasts become activated during wound repair and rapidly return to a ‘resting’ state, and are thus critical for normal tissue homeostasis and tumour development. A new study now reveals an important pro-tumorigenic role for the stress response in cancer-associated fibroblasts that may offer a new opportunity to limit tumour progression.

中文翻译：

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应激反应调节癌成纤维细胞

成纤维细胞在伤口修复过程中被激活并迅速恢复到“静止”状态，因此对于正常组织稳态和肿瘤发展至关重要。一项新的研究现在揭示了癌症相关成纤维细胞中应激反应的重要促肿瘤作用，这可能为限制肿瘤进展提供新的机会。