The adhesion and modification of wet surfaces by an interfacial adlayer remain a key challenge in chemistry and materials science. Herein, we report a transparent and biocompatible amyloid-like nanofilm that breaks through the hydration layer of a wet surface and achieves strong adhesion with a hydrogel/tissue surface within 2 s. This process is facilitated by fast amyloid-like protein aggregation at the air/water interface and the resultant exposure of hydrophobic groups. The resultant protein nanofilm adhered to a hydrogel surface presents an adhesion strength that is 20 times higher than the maximum friction force between the upper eyelid and eyeball. In addition, the nanofilm exhibits controllable tunability to encapsulate and release functional molecules without significant activity loss. As a result, therapeutic contact lenses (CLs) could be fabricated by adhering the functionalized nanofilm (carrying drug) on the CL surface. These therapeutic CLs display excellent therapeutic efficacy, showing an increase in cyclosporin A (CsA) bioavailability of at least 82% when compared to the commercial pharmacologic treatment for dry eye syndrome. Thus, this work underlines the finding that the bioinspired amyloid-like aggregation of proteins at interfaces drives instant adhesion onto a wet surface, enabling the active loading and controllable release of functional building blocks.

中文翻译：

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类淀粉样纳米膜与湿表面的即时粘附

界面adlayer对湿表面的粘附和改性仍然是化学和材料科学中的一个关键挑战。在这里，我们报告了一种透明且生物相容的类淀粉样纳米膜，它突破了湿表面的水合层，并在 2 秒内与水凝胶/组织表面实现了强粘附。这一过程通过在空气/水界面处的快速淀粉样蛋白聚集和由此产生的疏水基团的暴露而得到促进。粘附到水凝胶表面的所得蛋白质纳米膜的粘附强度比上眼睑和眼球之间的最大摩擦力高 20 倍。此外，纳米薄膜表现出可控的可调性来封装和释放功能分子，而没有明显的活性损失。因此，可以通过将功能化纳米膜（携带药物）粘附在 CL 表面上来制造治疗性隐形眼镜（CL）。这些治疗性 CL 显示出优异的治疗效果，与干眼综合征的商业药物治疗相比，环孢菌素 A (CsA) 的生物利用度增加了至少 82%。因此，这项工作强调了这一发现，即受生物启发的蛋白质在界面处的类淀粉样蛋白聚集驱动即时粘附到潮湿表面上，从而实现功能构件的主动加载和可控释放。与干眼症的商业药物治疗相比，环孢菌素 A (CsA) 的生物利用度增加了至少 82%。因此，这项工作强调了这一发现，即受生物启发的蛋白质在界面处的类淀粉样蛋白聚集驱动即时粘附到潮湿表面上，从而实现功能构件的主动加载和可控释放。与干眼症的商业药物治疗相比，环孢菌素 A (CsA) 的生物利用度增加了至少 82%。因此，这项工作强调了这一发现，即受生物启发的蛋白质在界面处的类淀粉样蛋白聚集驱动即时粘附到潮湿表面上，从而实现功能构件的主动加载和可控释放。