An N-heterocyclic carbene-catalyzed asymmetric [3 + 2] annulation of enals with propargylic ketimines for the facile and enantioselective construction of γ,γ-disubstituted pyrrolidin-2-ones has been developed. This potocol was featured with mild reaction conditions, wild functional group tolerance, easy scalability, and high level of enantioselectivity, which also enriched the chemistry of NHC-bound homoenolates involved synthesis of γ-lactams bearing γ-quaternary stereogenic centers from acyclic kitimimes.

中文翻译：

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N-杂环卡宾催化的对映选择性[3 + 2]烯醛与炔丙基亚胺的环化：获得带有季立体中心的γ，γ-二取代吡咯烷-2-酮

已经开发了一种N-杂环卡宾催化的不对称 [3 + 2] 烯醛与炔丙基酮亚胺的环化，用于轻松和对映选择性地构建 γ,γ-二取代吡咯烷-2-酮。该方案具有反应条件温和、官能团耐受性强、易于扩展和对映选择性高的特点，这也丰富了 NHC 结合的均烯醇化物的化学性质，包括从无环基亚甲基合成带有 γ-季铵立体中心的 γ-内酰胺。